000			04457nam a2200421 i 4500
999			_c12604 _d12604
001			28644453
005			20210224115805.0
008			930312s1993 paua b 001 0 eng
010			_a93060193
020			_a1566760046
035			_a.b33781990
035			_a5428107
040			_aDLC _cDLC _dIWO _dOSU _dUtOrBLW _dEG-NFue _erda
050			_aRS201.G44 _bP37 1993
050		0	_aRS201.G44 _bP37 1993
050	0	0	_aRS201.G44 _bP37 1993
082	0		_222 _a615.19 _bP.K.B
096			_aQV 748 P235 1993
100	1		_aPark, Kinam _eAuthor
245	1	0	_aBiodegradable hydrogels for drug delivery / _cKinam Park, Waleed S.W. Shalaby, Haesun Park
264		1	_aLancaster, PA : _bTechnomic Pub., _cc1993
264		4	_cc1993
300			_aix, 252 pages. : _billustrations. ; _c24 cm
336			_2rdacontent _atext
337			_2rdamedia _aunmediated
338			_2rdacarrier _avolume
504			_aIncludes bibliographical references and index
505	0		_aChapters, sub-chapters and selected sub-sections, some condensed for this space. All chapters end with a section of References. Introductiono Controlled Release Drug Delivery Systems o Hydrogels: Definition, Hydrogel as a Biomaterial, Biodegradable Hydrogels Biodegradationo Definitions: Bioresorption, Bioabsorption, Bioerosion, Biodeterioration o Mechanisms: Solubilization, Charge Formation Followed by Dissolution o Chemical Hydrolysis of Polymers:Enzyme-Catalyzed Hydrolysis o Biodegradable Hydrogels Types of Biodegradable Hydrogelso Hydrogels with Degradable Polymer Backbone: Crosslinked Hydrogels, Noncrosslinked Hydrogels o Hydrogels with Degradable Crosslinking Agents: Crosslinked with Small Molecules, Crosslinked with Oligopeptides, Crosslinked with Macromolecules o Hydrogels with Degradable Pendant Chains Chemical Gelso Polymerization in the Presence of Crosslinking Agents: Introduction of Double Bonds to Macromolecules, Determination of Double Bonds on the Macromonomers o Crosslinking of Water-Soluble Polymers: Crosslinking with Functional Groups, Nonspecific Crosslinking, Determination of the Degree of Crosslinking Physical Gelso Thermoreversible Gelling System: Gels with Thermomelting Properties,Gels with Thermogelation Properties o Thermoreversible Gelling Polysaccharides: Water-Soluble Polysaccharides, Gel-Forming Polysaccharides o Physical Gelation by Ion Complexation: Polymers with Hydroxyl Groups, Carrageenan, Gellan, Pectin, Alginate, Polyphosphazenes, Other Polyanions, Chitosan o Physical Gelation by Specific Interactions: Fibrin Gel, Mucus Gel, Actin Gel, Avidin-Biotin Mediated Gel, Antibody Mediated Gel, Lectin-Mediated Gel oDetermination of the Crosslink Density Chemically-Induced Degradationo Chemically-Induced Hydrolysis in the Body: Distribution and Elimination, Factors Influencing Chemically-Induced Hydrolysis o Chemically-Induced Hydrolysis of Polyesters: Poly(glycolic Acid), Poly(lactic Acid), Polycaprolactone, Poly(ethylene Terephthalate), Poly(ss-hydroxybutyrate), Polydioxanone o Polyester Hydrogels Enzyme-Catalyzed Degradationo Properties of Enzymes o Hydrolytic Enzymes in the Body: Gastrointestinal Tract, Reticuloendothelial System, Others o Factors Influencing Enzyme-Catalyzed Reactions: Conformation of Enzymes and Substrates, Presence of Polymer Molecules o Enzyme-Catalyzed Degradation of Modified Proteins: Albumin, Gelatin, Modified Enzymes o Enzyme-Catalyzed Degradation of Modified Polysaccharides: Dextran, Starch, Amylose, Chitosan, Chondroitin-6-Sulfate Biodegradable Drug Delivery Systemso Mechanisms of Drug Release: Diffusion-Controlled Systems, Swelling-Controlled Systems, Biodegradable Systems o Drug Release From Hydrogels with Biodegradable Backbones: Hydrogels Based on Protein/Polypeptides, Hydrogels Based on Polysaccharides, Biodegradable Hydrogels Based on Polyesters o Drug Release From Hydrogels with Degradable Crosslinking Agents: Hydrogels Crosslinked with Small Molecules, Hydrogels Crosslinked with Albumin o Drug Release from Hydrogels with Biodegradable Pendant Chains Future Developmento Drug Loading o Drug Targeting o Drug Releaseo Degradation and Elimination o Use of Bioactive Polymers
650		0	_aGels (Pharmacy)
650		0	_aColloids in medicine
650		0	_aBiodegradation
650		0	_aDrug delivery systems
650		2	_aDrug Delivery Systems
700	1		_aShalaby, Waleed S. W _eAuthor
700	1		_aPark, Haesun _eAuthor
942			_2ddc _cBK