000			02872cam a2200361 i 4500
999			_c12663 _d12663
001			40075909
005			20210228120433.0
008			981002s1999 dcua bf 001 0 eng c
010			_a98043913
020			_a0917330730 (pbk.)
035			_a.b21007159
040			_aDNLM/DLC _cDLC _dNLM _dOCL _dEG-NFue _erda
050	0	0	_aRM301.5 _b.R57 1999
060	0	0	_aQV 38 _bR612h 1999
082	0	0	_a615.7 _221 _bR.W.H
100	1		_aRitschel, W. A. _q(Wolfgang A.) _eAuthor.
245	1	0	_aHandbook of basic pharmacokinetics-- including clinical applications / _cWolfgang A. Ritschel, Gregory L. Kearns
250			_afifth edition
264		1	_aWashington, D.C. : _bAmerican Pharmaceutical Association, _cc1999
264		4	_cc1999
300			_axiv, 563 pages. : _billustrations. ; _c22 cm
336			_2rdacontent _atext
337			_2rdamedia _aunmediated
338			_2rdacarrier _avolume
504			_aIncludes bibliographical references and index
505	0		_a1. Definitions and glossary -- 2. LADMER system -- liberation, absorption, distribution, metabolism, elimination, and response -- 3. Organs, tissues, cells, and organelles -- 4. Cell membranes -- 5. Drug-receptor interactions -- 6. Absorption/transport mechanisms -- 7. pK[subscript a] and degree of ionization -- 8. Lipid/water partition coefficient -- 9. Physicochemical factors altering biological performance of drugs -- 10. Biopharmaceutical data of the gastrointestinal tract -- 11. Fluid compartments and circulatory system -- 12. Binding of drugs to biological material -- 13. Drug biotransformation -- 14. Compartment models -- 15. Determination of rate constants -- 16. Volume of distribution and distribution coefficient -- 17. Excretion and clearance of drugs -- 18. Urinary and biliary recycling -- 19. Cumulative urinary excretion -- 20. Area under the blood level-time curve -- 21. Pharmacokinetics of single dose administration -- 22. Pharmacokinetics of multiple dosing -- 23. Compartment model independent analysis -- 24. Pediatric pharmacokinetics -- 25. Drug dosage in elderly patients -- 26. Drug dosage in obese patients -- 27. Drug disposition in pregnancy -- 28. Dosage regimen design -- 29. Drug monitoring and dose adjustment -- 30. Physiological and pathological factors influencing drug response -- 31. First dose size in man -- 32. Forensic pharmacokinetics -- 33. Nonlinear pharmacokinetics -- 34. Curve fitting -- 35. Correlation of clinical response with drug disposition -- 36. Bioavailability and bioequivalence -- 37. Body surface areas -- 38. Extracorporeal methods of drug removal -- 39. Pharmacogenetics and pharmacogenomics.
650		0	_aPharmacokinetics _vHandbooks, manuals, etc
650		2	_aPharmacokinetics
655		2	_aHandbooks
700	1		_aKearns, Gregory L _eAuthor.
942			_2ddc _cBK