000			03273cam a22004694a 4500
999			_c12727 _d12727
001			741293
005			20210302130519.0
008			990318s1999 nyua b 001 0 eng c
010			_a 99026168
020			_a0824719832 (acidfree paper)
040			_aEG-NcFUE _cEG-NcFUE _erda
042			_apcc
050	0	0	_aRS199.F74 _bF74 1999
060	1	0	_aW1 _bDR893B v.96 1999
060	1	0	_aQH 324.9 _bF857 1999
082	0	0	_221 _a615.19 _bF
245	0	0	_aFreeze-drying/lyophilization of pharmaceutical and biological products / _cedited by Louis Rey, Joan C. May.
264		1	_aNew York : _bMarcel Dekker, _c[1999]
264		4	_a©1999.
300			_aix, 477 pages : _billustrations ; _c24 cm.
336			_2rdacontent _atext
337			_2rdamedia _aunmediated
338			_2rdacarrier _avolume
490	1		_aDrugs and the pharmaceutical sciences ; _v96
504			_aIncludes bibliographical references and index.
505	0		_aGlimpses into the realm of freeze-drying - classical issues and new ventures; potential energy surfaces, computer simulations, and the structure of water; structural and dynamic properties of bulk and confined water; experimental freeze-drying procedures and equipment; freezing and drying-induced perturbations of protein structure and mechanisms of protein protection by stabilizing additives; mechanisms of protein stabilization during freeze-drying and storage - the relative importance of thermodynamic stabilization and glassy state relaxation dynamics; the regulatory control of freeze-dried products - importance and evaluation of residual moisture; basic aspects and industrial strategies for the preservation of microorganisms by freezing and drying; industrial freeze-drying for pharmaceutical applications; industrial freeze-drying of vaccines destined for veterinary purposes - an overview; manufacturing principles of freeze-dried collagen sponges - characteristics and applications; lyophilization process validation; critical steps in the preparation of elastomeric closures for biopharmaceutical freeze-dried products; technical procedures for operation of cleaning in place and sterilization in place process for production freeze-drying equipment; studies on the development of manufacturing processes for pharmaceutical freeze-dried products; potential prospects in freeze-drying.
520			_aHighlights the application of freeze-drying to pharmaceuticals, illustrating practical and industry-tested methods of preserving and reactivating delicate biologicals and biochemicals. The text discusses the basic principles and engineering aspects of lyophilization.
650		0	_aFreeze-drying.
650		0	_aDrugs _xDrying.
650		0	_aBiological products _xDrying.
650	1	2	_aFreeze Drying _xmethods.
650	2	2	_aBiological Products.
650	2	2	_aPharmaceutical Preparations.
700	1		_aRey, Louis. _eauthor
700	1		_aMay, Joan C. _q(Joan Christine) _eauthor
830		0	_aDrugs and the pharmaceutical sciences ; _vv. 96.
906			_a7 _bcbc _corignew _d1 _eocip _f19 _gy-gencatlg
942			_2ddc _cBK