000			02422aam a2200289 i 4500
999			_c12763 _d12763
001			32314693
005			20210303112436.0
008			941021t19951995paua b 001 0 eng
010			_a94061269
020			_a1566762049
040			_aDLC _beng _erda _cDLC _dNLM
050			_aRM301.5 _b.B67 1995
082		4	_222 _a615.70151 _bB.D.M
100	1		_aBourne, D. W. A. _q(David W. A.), _d1946- _eauthor.
245	1	0	_aMathematical modeling of pharmacokinetic data / _cDavid W.A. Bourne
264		1	_aLancaster, Pa. : _bTechnomic Pub. Co., _c[1995]
264		4	_c©1995
300			_ax, 139 pages : _billustrations ; _c24 cm
336			_atext _btxt _2rdacontent
337			_aunmediated _bn _2rdamedia
338			_avolume _bnc _2rdacarrier
504			_aIncludes bibliographical references (pages 133-136) and index
505	0		_aCover -- Half Title -- Title Page -- Copyright Page -- Dedication -- Table of Contents -- Preface -- Chapter 1: Why Model the Data? -- 1.1 Condense the Data -- 1.2 Exploring Mechanisms -- 1.3 Making Predictions -- Chapter 2: General Approach -- 2.1 General Method -- 2.2 Error in y Alone -- 2.3 Parameter Adjustments -- Chapter 3: Pharmacokinetic Models -- 3.1 Compartmental Models -- 3.2 Physiologically Based Models -- 3.3 Pharmacodynamic Models -- Chapter 4: Simulation of Data -- 4.1 Explicit Equations -- 4.2 Implicit Equations -- 4.3 Differential Equations -- 4.4 Integration Using Laplace Transforms -- 4.5 Numerical Integration of Differential Equations -- Chapter 5: Initial Estimates -- 5.1 Graphical Methods -- 5.2 Linear Regression -- 5.3 Curve Stripping -- 5.4 Area under the Curve Estimation -- 5.5 Deconvolution -- Chapter 6: Nonlinear Regression -- 6.1 Grid Search Method -- 6.2 Steepest Descent Method -- 6.3 Gauss-Newton Methods -- 6.4 Simplex Method -- 6.5 Local Minima -- Chapter 7: Weighting Schemes -- 7.1 Equal Weight -- 7.2 Variance Model -- 7.3 Iteratively Reweighted Least Squares -- 7.4 Extended Least Squares -- 7.5 Bayesian Methods -- 7.6 Analysis of Population Data -- Chapter 8: Evaluation of Program Output -- 8.1 Tabular Output -- 8.2 Graphical Output -- 8.3 Statistical Output -- Chapter 9: Experimental Design -- 9.1 Pilot Study -- 9.2 Identifiability-Sampling Sites -- 9.3 Optimal Sampling-Sampling Times -- 9.4 Model Testing -- Appendix -- References -- Index
650		0	_aPharmacokinetics _xMathematical models
942			_2ddc _cBK