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008			090515t20092009dcua bf 001 0 eng
010			_a 2009020352
016	7		_a101505048 _2DNLM
020			_a9781582121260
020			_a1582121265
029	1		_aNLGGC _b322211026
029	1		_aNLM _b101505048
029	1		_aAU@ _b000044237774
035			_a(OCoLC)ocn313655800
035			_a(WU)8145900-uwmadisondb
035			_a(EXLNZ-01UWI_NETWORK)9910080892002121
040			_aDNLM/DLC _beng _cDLC _dYDX _dBTCTA _dNLM _dGZH _erda
042			_apcc
049			_aGZHA
050	0	0	_aRM301.5 _b.R57 2009
060	0	0	_a2009 L-272
060	1	0	_aQV 39 _bR612h 2009
082	0	0	_a615.7 _222 _bR.W.H
100	1		_aRitschel, W. A. _q(Wolfgang A.) _eauthor
245	1	0	_aHandbook of basic pharmacokinetics-- including clinical applications / _cWolfgang A. Ritschel, Gregory L. Kearns.
250			_aSeventh edition.
264		1	_aWashington, D.C. : _bAmerican Pharmacists Association, _c[2009]
264		4	_c©2009
300			_axii, 490 pages : _billustrations ; _c27 cm
336			_atext _btxt _2rdacontent
337			_aunmediated _bn _2rdamedia
338			_avolume _bnc _2rdacarrier
504			_aIncludes bibliographical references and index.
505	0	0	_a1. Definitions and Glossary.2. The LADMER System: Drug Liberation, Absorption, Distribution, Metabolism, Elimination, and Response.3. Organs, Tissues, Cells, and Organelles.4. Cell Membranes-Structure, Functions, and Properties.5. Drug Receptor Interactions.6. Absorption/Transport Mechanisms.7. PKa and Degree of Ionization.8. Lipid/Water Partition Coefficient.9. Physico-Chemical Factors Altering Biological Perfor- mance of Drugs.10. Biopharmaceutical Data of the Gastrointestinal Tract.11. Fluid Compartments and Circulatory System (Blood and Lymph).12. Binding of Drugs to Biological Material13. Drug Biotransformation.14. Compartment Models.15. Determination of Rate Constants.16. Volume of Distribution and Distribution Coefficient.17. Excretion and Clearance of Drugs.18. Urinary and Biliary Recycling.19. Cumulative Urinary Excretion.20. Area Under the Blood Level-Time Curve.21. Pharmacokinetics of Single Dose Administration.22. Pharmacokinetics of Multiple Dosing.23. Compartment Model Independent Analysis.24. Pediatric Pharmacokinetics.25. Drug Dosage in Elderly Patients.26. Drug Dosage in Obese Patients.27. Drug Disposition in Pregnancy.28. Dosage Regimen Design.29. Drug Monitoring and Dose Adjustment.30. Physiological and Pathological Factors Influencing Drug Response.31. First Dose Size in Man.32. Forensic Pharmacokinetics.33. Nonlinear Pharmacokinetics.34. Curve Fitting.35. Correlation of Clinical Response with Drug Disposition.36. Bioavailability and Bioequivalence.37. Body Surface Area.38. Extracorporeal Methods of Drug Removal.39. Pharmacogenetics and Pharmacogenomics.Appendix.Index.
650		0	_aPharmacokinetics _vHandbooks, manuals, etc.
650		0	_aClinical pharmacology _vHandbooks, manuals, etc.
650	1	2	_aPharmacokinetics _vhandbooks.
700	1		_aKearns, Gregory L. _eauthor
710	2		_aAmerican Pharmacists Association.
942			_2ddc _cBK
949			_a20091217 _brkr _cd _dnt _ep _fcall:n _grepl:n _hhsl