000			03276cam a22003974i 4500
999			_c12858 _d12858
001			41540227
005			20210419142047.0
008			990603s1999 nyua b 001 0 eng
010			_a99032806
020			_a0824719956 (alk. paper)
040			_aDLC _cDLC _dEG-NcFUE _beng _erda
042			_apcc
050	1	0	_aRS201.B54 _bB567 1999
050	1	0	_aRS201.B54 _bB567 1999
060	0	0	_aW1 _bDR893B v.98 1999
060	1	0	_aWB 340 _bB615 1999
082	0	0	_a615.58 _221 _bB
245	0	0	_aBioadhesive drug delivery systems : _bfundamentals, novel approaches, and development / _cedited by Edith Mathiowitz, Donald E. Chickering III, Claus-Michael Lehr
264		1	_aNew York : _bMarcel Dekker, _c[1999]
264		4	_c©1999
300			_axv, 670 pages : _billustrations ; _c23 cm.
336			_2rdacontent _atext _btxt
337			_2rdamedia _aunmediated _bn
338			_2rdacarrier _avolume _bnc
490	0		_aDrugs and the pharmaceutical sciences ; _vv. 98
504			_aIncludes bibliographical references and index
505	0		_aI.Fundamentals of bioadhesion -- Definitions, mechanisms, and theories of bioadhesion -- The role of water movement and polymer hydration in mucoadhesion -- A rheological approach to explain the mucoadhesive behavior of polymer hydrogels -- Functional histology of epithelia relevant for drug delivery: respiratory tract, digestive tract, eye, skin, and vagina -- Biochemical and functional aspects of mucus and mucin-type glycoproteins -- II.Methods of evaluating bioadhesive interactions -- Adaptation of a microbalance to measure bioadhesive properties of microspheres -- Novel magnetic technique to measure bioadhesion -- Principles of skin adhesion and methods for measuring adhesion of transdermal systems -- Force microscopy of cells to measure bioadhesion -- Direct measurement of molecular-level forces and adhesion in biological systems -- A centrifugation method for measurement of two-dimensional binding characteristics of receptor-ligand interaction -- III.Novel concepts and strategies for bioadhesive drug delivery systems -- Multifunctional polymers for the peroral delivery of peptide drugs -- Chitosan and chitosan derivatives as absorption enhancers for peptide drugs across mucosal epithelia -- Plant lectins for oral drug delivery to different parts of the gastrointestinal tract -- Bacterial invasion factors and lectins as second-generation bioadhesives -- Novel PEG-containing acrylate copolymers with improved mucoadhesive properties --Bioadhesive, bioerodible polymers for increased intestinal update -- IV.Development issues of bioadhesive drug delivery systems: products and clinical trials -- Novel formulation approaches to oral mucoadhesive drug delivery systems -- Bioadhesive formulations for nasal peptide delivery -- Development of bioadhesive buccal patches -- Vaginal delivery of calcitonin by hyaluronic acid formulations -- Ocular bioadhesive drug delivery systems -- bioadhesive preparations as topical dosage forms
650		0	_aBioadhesive drug delivery systems
650	1	2	_aDrug Delivery Systems
650	2	2	_aAdhesiveness
700	1		_aMathiowitz, Edith, _d1952-
700	1		_aChickering, Donald E
700	1		_aLehr, Claus-Michael, _d1961-
942			_2ddc _cBK