000			02272cam a2200445 a 4500
999			_c12890 _d12890
001			49650002
005			20210307120559.0
008			020107s2001 nyua b 001 0 eng d
010			_a2002275620
020			_a0824793625 _c(alk. paper)
040			_aEG-NcFUE _cEG-NcFUE _dEG-NcFUE _erda
050	0	0	_aQP632.E4 _bP43 2001
082	0	4	_223 _a616.01 _bW.K.E
100	1		_aWilliams, Kevin L _eauthor
245	1	0	_aEndotoxins : _bpyrogens, LAL testing, and depyrogenation / _cKevin L. Williams ; with contributions by Karen Roberts, N. Anthony Nnalue
250			_aSecond edition, revised and expanded
264		1	_aNew York : _bMarcel Dekker, _c[2001]
264		4	_a©2001
300			_ax, 372 pages : _billustrations ; _c24 cm
336			_2rdacontent _atext
337			_2rdamedia _aunmediated
338			_2rdacarrier _avolume
440		0	_aDrugs and the pharmaceutical sciences ; _vv. 111
500			_a1st ed. was published as Pyrogens: endotoxins and LAL testing and depyrogenation, by F. C. Pearson
504			_aIncludes bibliographical references and index
505	0		_aHistorical foundations of pyrogen research; pyrogen, endotoxin, and fever - an overview; endotoxin structure, function, activity; the host response to endotoxin; non-endotoxin microbial pyrogens (lesser endotoxins and superantigens); non-microbial exogenous pyrogens and drug fever; pharmaceutical manufacturing contamination control; endotoxin as a standard; the rabbit pyrogen test; LAL discovery, mechanism, and application; LAL assay development, validation and regulation.
520			_aThis study describes the environmental presence, detection, properties and biological structure and function of endotoxins in parenteral manufacturing. It includes chapters on asay development, automation, depyrogenation, and regulation of testing by LAL methods.
650		0	_aEndotoxins _xAnalysis
650		0	_aPyrogens _xAnalysis
650		0	_aLimulus test
650		0	_aDrugs _xMicrobiology
650		2	_aEndotoxins _xanalysis
650		2	_aInfusions, Parenteral _xstandards
650		2	_aLimulus Test
650		2	_aPyrogens _xanalysis
700	1		_aWeary, Marlys _ejoint author
700	1		_aJorgensen, James H _ejoint author
942			_2ddc _cBK