000			04302ntm a2200313 i 4500
999			_c12943 _d12943
001			12102116
005			20211024132905.0
008			150118s2020 ua a f bm 000 0 eng |
040			_aEG-EULC _cEG-EULC _erda
041	0		_aeng _bara
082	0	4	_a615.1 _bB.D.E _222
100	1		_aEl Bohy, Doaa Mohamed Salah Diab. _933872 _eauthor.
245	1	0	_aEffect of pantoprazole and esmoprazole on the cyclosporine blood concentration in a kideny transplant recipient / _cDoaa Mohamed Salah Eldian Diab El Bohy, (M.Sc. pharm. Sci. clinical pharmacy, 2012, assistant lecturer of Clinical pharmacy , faculty of pharmacy, Future university); Supervisors Manal Hamed El Hamamsy, (Ph. D. Professor of Clinical pharmacy, faculty of pharmacy, Ain Shams University), Magdy Mohamed El Sharkawy, M.D., (Professor of internal medicine & Nephrology, faculty of medicine, Ain Shams University), Soheir Abo El-Azm Diab, Ph. D., (professor of pharmacology, faculty of medicine, Cairo University), Waleed Ahmed Bchari, M.D., (Associate Professor of internal medicine & Nephrology, faculty of medicine, Ain Shams University), Sara Mahmoud Shahin, Ph. D., (Associate Professor of Clinical pharmacy, faculty of pharmacy, Ain Shams University).
246	1	5	_aتأثير عقاري البانتوبرازول و الازموبرازول على تركيز عقار السيكلوسبورن في دم مرضى زرع الكلي
264		1	_c2020
300			_a96 pages, 3 pages : _billustrations (some color) ; _c24 cm
336			_2rdacontent _atext
337			_2rdamedia _aunmediated
338			_2rdacarrier _avolume
500			_aSupervisors Manal Hamed El Hamamsy, (Ph. D. Professor of Clinical pharmacy, faculty of pharmacy, Ain Shams University), Magdy Mohamed El Sharkawy, M.D., (Professor of internal medicine & Nephrology, faculty of medicine, Ain Shams University), Soheir Abo El-Azm Diab, Ph. D., (professor of pharmacology, faculty of medicine, Cairo University), Waleed Ahmed Bchari, M.D., (Associate Professor of internal medicine & Nephrology, faculty of medicine, Ain Shams University), Sara Mahmoud Shahin, Ph. D., (Associate Professor of Clinical pharmacy, faculty of pharmacy, Ain Shams University).
502			_aThesis (Ph.D.)-Ain Shams university, Faculty of pharmacy, Department of Clinical pharmacy, 2020.
504			_aIncludes bibliographical references.
520	3		_aRenal allograft survival requires multiple immunosuppressive drugs. This strategy may lead to gastric complications that necessitate gastro-protective medications, notably, proton pump inhibitors (PPI). This study aimed to compare the influence of pantoprazole and esomeprazole on serum cyclosporine trough levels (C0) in renal transplant recipients (RTR). A prospective, parallel, open-label trial was conducted on 47 adult RTR receiving cyclosporine doses adjusted to attain trough concentrations of 100 to 150 μg/L, mycophenolate mofetil (MMF) 750 mg q12 hour and prednisolone at 5 mg daily at Nasser Institute, Cairo, Egypt from January to September 2016. Patients were randomized into the esomeprazole group (25) or pantoprazole group (22) receiving the same dose (40 mg once daily). The study outcomes included clinical signs of rejection and renal function decline, assessed by elevations in serum creatinine, caused by cyclosporine level variations in either of the two study groups. Renal function, C0 and CBC measurements were measured at baseline and monthly for 6 months. The mean C0 values were higher in the pantoprazole group than in the esomeprazole group in the sixth month only (P = .007). Serum creatinine level was lower in the sixth month than at baseline in the esomeprazole group (P = .004). There were no signs of rejection biochemical or clinical in any of the study groups. In conclusion, PPIs should be used with caution and doses should be titrated to reach the C0 targets in RTR, which is of more importance in pantoprazole than esomeprazole to avoid C0 level elevation or decline affecting the allograft function
546			_aText in English, abstracts in English and Arabic.
650		0	_aClinical Pharmacy
856	4	0	_3DSpace electronic resource _uhttp://repository.fue.edu.eg/xmlui/handle/123456789/5773
942			_cTHESIS _2ddc