000 03759ntm a2200325 i 4500
999 _c12945
_d12945
001 12102116
005 20211025112156.0
008 150118s2020 ua a f bm 000 0 eng |
040 _aEG-EULC
_cEG-EULC
_erda
041 0 _aeng
_bara
082 0 4 _bI.E.P
_222
_a615.19
100 1 _aIbrahim, Enas El-Maghawry,
_933874
_eauthor.
245 1 0 _aA pharmaceutical study on colon-targeted delivery systems of an anti-inflammatory drug /
_cEnas El-Maghawry Ibrahim, (assistant lecturer, department of Pharmaceutics & Pharmaceutical Technology, Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Future University in Egypt), supervision of Prof. Dr. Ahmed Abd-Elbary (Professor of Pharmaceutics and Industrial Pharmacy, Ex-Dean of Faculty of Pharmacy, Cairo University, Beni SweifUniversity), Prof. Dr. Seham Elkheshen, (Professor of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University), Prof. Dr. Mina Ibrahim Tadros, (Professor of Pharmaceutics and Industrial Pharmacy, Dean of Faculty of Pharmacy and Drug Technology, Egyptian Chinese University).
246 1 5 _aدراسة صيدلية على بعض الأنظمة الهادفة للقولون المحتوية على عقار مضاد للالتهاب
264 1 _c2020
300 _ax, 212 pages, 6 pages :
_billustrations (some color) ;
_c24 cm
336 _2rdacontent
_atext
337 _2rdamedia
_aunmediated
338 _2rdacarrier
_avolume
500 _asupervision of Prof. Dr. Ahmed Abd-Elbary (Professor of Pharmaceutics and Industrial Pharmacy, Ex-Dean of Faculty of Pharmacy, Cairo University, Beni Sweif University), Prof. Dr. Seham Elkheshen, (Professor of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University), Prof. Dr. Mina Ibrahim Tadros, (Professor of Pharmaceutics and Industrial Pharmacy, Dean of Faculty of Pharmacy and Drug Technology, Egyptian Chinese University).
502 _aThesis (Ph.D.)- Cairo university, Faculty of pharmacy, Department of Pharmaceutics and industrial Pharmacy, 2020.
504 _aIncludes bibliographical references.
520 3 _aColon-targeted drug delivery has been the focus of numerous studies due to its potential to improve treatment of local diseases affecting the colon, while minimizing systemic drug side effects. Some examples of the diseases which impact the colon include Crohn’s disease (CD) and ulcerative colitis (UC). In literature, different strategies have been used to target the inflamed colon after oral drug administration. Strategies for specific colon drug delivery include the utilization of pro-drugs, exploitation of higher colonic pH values, and enzymatic activity of colonic micro flora, intestinal transit time and colonic pressure. In general, dimensions of the delivery system greatly influence the targeting of the inflamed colon. Size-dependency of particles has a considerable impact on their epithelial uptake. A favoured accumulation in the inflamed colon tissues has been found for particles having sizes in the nanometer-range. It has been shown in experimental colitis models that nanosized particles are more readily uptaken by cells that are immune-related such as macrophages or dendritic cells in the site of active inflammation. The nano spray drying is one of the advanced technologies to produce nanoparticles. The nano spray dryer can produce relatively high yield of nanosized particles which possess narrow particle size distributions.
546 _aText in English, abstracts in English and Arabic.
650 0 _aPharmaceutical industry
650 0 _aPharmacology
856 4 0 _3DSpace electronic resource
_uhttp://repository.fue.edu.eg/xmlui/handle/123456789/5777
942 _cTHESIS
_2ddc