000			03411ntm a2200301 i 4500
999			_c12950 _d12950
001			12102116
005			20221103130733.0
008			150118s2019 ua a f bm 000 0 eng |
040			_aEG-EULC _cEG-EULC _erda
041	0		_aeng _bara
082	0	4	_a615.321 _bG.E.P _222
100	1		_aGabal, Eman Mohamed Salah Ibrahim _933878 _eauthor.
245	1	0	_aPharmacognostical and biological study of a plant from genus Acacia belonging to the family Fabaceae / _cBy Eman Mohamed Salah Ibrahim Gabal, BSc. in Pharmaceutical sciences and pharmaceutical industries, Faculty of Pharmacy, Future University In Egypt.
246	1	5	_aدراسة عقاقيرية و بيولوجية لنبات من جنس أكاشيا ينتمي للعائلة البقولية
264		1	_c2019
300			_a241 pages, 3 pages : _billustrations (some color) ; _c24 cm
336			_2rdacontent _atext
337			_2rdamedia _aunmediated
338			_2rdacarrier _avolume
500			_aProf. Dr. Hesham Soliman Mohamed Soliman, (Professor of Pharmacognosy- Pharmacognosy Department- Vice Dean of Education and Student Affairs- Faculty of Pharmacy- Helwan University), Prof. Dr. Mariam Hussein Abd El Hameed Gonaid, (Professor of Pharmacognosy- Pharmacognosy Department- Faculty of Pharmacy, Cairo University, Future University In Egypt.), Dr. Reham Ragaei Ibrahim, (Lecturer of Pharmacognosy- Pharmacognosy Department- Faculty of PharmacyHelwan University).
502			_aThesis (M.Sc.)-Helwan university, Faculty of pharmacy, Department of Pharmacognsy, 2019.
504			_aIncludes bibliographical references.
520	3		_aRenal allograft survival requires multiple immunosuppressive drugs. This strategy may lead to gastric complications that necessitate gastro-protective medications, notably, proton pump inhibitors (PPI). This study aimed to compare the influence of pantoprazole and esomeprazole on serum cyclosporine trough levels (C0) in renal transplant recipients (RTR). A prospective, parallel, open-label trial was conducted on 47 adult RTR receiving cyclosporine doses adjusted to attain trough concentrations of 100 to 150 μg/L, mycophenolate mofetil (MMF) 750 mg q12 hour and prednisolone at 5 mg daily at Nasser Institute, Cairo, Egypt from January to September 2016. Patients were randomized into the esomeprazole group (25) or pantoprazole group (22) receiving the same dose (40 mg once daily). The study outcomes included clinical signs of rejection and renal function decline, assessed by elevations in serum creatinine, caused by cyclosporine level variations in either of the two study groups. Renal function, C0 and CBC measurements were measured at baseline and monthly for 6 months. The mean C0 values were higher in the pantoprazole group than in the esomeprazole group in the sixth month only (P = .007). Serum creatinine level was lower in the sixth month than at baseline in the esomeprazole group (P = .004). There were no signs of rejection biochemical or clinical in any of the study groups. In conclusion, PPIs should be used with caution and doses should be titrated to reach the C0 targets in RTR, which is of more importance in pantoprazole than esomeprazole to avoid C0 level elevation or decline affecting the allograft function
546			_aText in English, abstracts in English and Arabic.
650			_aPharmacognosy
942			_cTHESIS _2ddc