| 000 | 03462ntm a2200325 i 4500 | ||
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_c13005 _d13005 |
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| 001 | 12102116 | ||
| 005 | 20211110105737.0 | ||
| 008 | 150118s2021 ua a f bm 000 0 eng | | ||
| 040 |
_aEG-EULC _cEG-EULC _erda |
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| 041 | 0 |
_aeng _bara |
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| 082 | 0 | 4 |
_a615.321 _bE.Y.C _222 |
| 100 | 1 |
_aElkhawas, Yasmin Alaa Eldin Ahmed, _933894 _eauthor. |
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| 245 | 1 | 0 |
_aChemical and biological evaluation of bioactive secondary metabolites from endophytic fungi Isolated from marine organisms / _c By Yasmin Alaa Eldin Ahmed Elkhawas, assistant lecturer Pharmacognosy, Faculty of Pharmacy, Future University in Egypt. |
| 246 | 1 | 5 | _aالتقييم الكميائي والحيوى لمركبات الأيض الثانوية النشطة حيويا من الفطريات المتكافلة المفصولة من الكائنات البحرية |
| 264 | 1 | _c2021 | |
| 300 |
_a140 pages, 3 pages : _billustrations (black and white) ; _c24 cm |
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| 336 |
_2rdacontent _atext |
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| 337 |
_2rdamedia _aunmediated |
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| 338 |
_2rdacarrier _avolume |
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| 500 | _aUnder the Supervision of Prof. Dr. Abdel Nasser B. Singab, Professor of Pharmacognosy, Head of Drug Discovery Research and Development Center- Faculty of Pharmacy- Ain Shams University, Prof. Dr. Osama M. Salama, Professor of Pharmacognosy, Former Vice President- Future University in Egypt, Associate Prof. Dr. Eman K. Alsayed, Associate Professor of Pharmacognosy, Faculty of Pharmacy - Ain Shams University, Associate Prof. Dr. Nada M. Mostafa, Associate Professor of Pharmacognosy, Faculty of Pharmacy - Ain Shams University, Dr. Mokhtar M. Bishr ,Technical Director, Plant Manager of Arab Co. For Pharmaceuticals & Medicinal Plants (Mepaco) | ||
| 502 | _aThesis (Ph.D.)-Ain Shams university, Faculty of pharmacy, Department of Pharmacognosy, 2021. | ||
| 504 | _aIncludes bibliographical references. | ||
| 520 | 3 | _aTwo marine derived fungi were isolated from Red sea soft coral Sarcophyton ehrenbergi, namely, Aspergillus flavus and A. nomius. These fungi were cultured using solid rice media. Chromatographic studies on different extracts, resulted in isolation of 15 compounds. These compounds were classified according to their chemical nature into six categories: (1) pyrones, (2) cyclodepsipeptides, (3) diketopiperazines, (4) indoles, (5) benzo-furanones (6) steroids, using different tools of spectroscopic techniques. Furthermore, these compounds were confirmed by LC-MS/MS. Regarding the bioactivities of the extracts and the isolated compounds, two compounds scopularides A & B from A. flavus showed antifungal, anti-H. pylori and anti -TB activities . Scopularide A showed potent antifungal, anti-H- pylori activities while scopularide B revealed potent activity only against Candida albicans and H- pylori. Moreover, the total extract of A. flavus showed larvicidal activity due to the presence of these two scopularides. The larvicidal and antimicrobial activities were confirmed by carrying out in-silico molecular docking against Candida albicans, A. niger, and also against certain biochemical enzymes to identify the mode of action by which these tested samples exerts their activity. | |
| 546 | _aText in English, abstracts in English and Arabic. | ||
| 650 | 0 | _aPharmacognosy | |
| 650 | 0 | _aMedicinal plants | |
| 856 | 4 | 0 |
_3DSpace electronic resource _uhttp://repository.fue.edu.eg/xmlui/handle/123456789/5866 |
| 942 |
_cTHESIS _2ddc |
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