000			04165ntm a2200361 i 4500
001			12102116
005			20230810142138.0
008			150118s2021 ua a f bm 000 0 eng |
040			_aEG-NcFUE _erda
041	0		_aeng _bara
082	0	4	_a615.19 _bM.Z.A _222
100	1		_aMazayen, Zaed Mazen _eauthor
245	1	0	_aApplication of Nanosizing Technique for Enhancement of Solubility of a Certain Drug / _cZaed Mazen Mazayen, B.SC of Pharmaceutical Sciences and Pharmaceutical Industries 2016, Faculty of Pharmacy, Future University in Egypt In partial fulfillment of the requirements for the degree of Master in Pharmaceutical Sciences Pharmaceutics and Pharmaceutical Technology Under the supervision of Prof. Dr. Ehab Rasmy Bendas Professor of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Future University, Prof. Dr. Emad Bashir Basalious Professor of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University Dr. Rasha Elbatanony Lecturer of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Future University in Egypt.
246	3	5	_aتطبيق تقنية تصغير الحجم الى النانومتري لتعزيز الذوبان لدواء معين
264		1	_c2021
300			_a123 pages, 5 pages : _billustrations (some color) ; _c24 cm.
336			_atext _2rdacontent
337			_aunmediated _2rdamedia
338			_avolume _2rdacarrier
500			_asupervision of Prof. Dr. Omaima A. Sammour, (Professor of Pharmaceutics and Industrial Pharmacy-Faculty of Pharmacy- Ain Shams University), Prof. Dr. Mona Ibrahim Abdeltawab Elassal, (Professor of Pharmaceutics and Industrial Pharmacy- Faculty of Pharmacy- Future university), Dr. Mona Mohamed Ahmed Abdel-Mottaleb, (Associate professor of Pharmaceutics and Industrial Pharmacy-Faculty of Pharmacy- Ain Shams University).
502			_aThesis (M.Sc.)-Ain Shams university, Faculty of pharmacy, Department of Pharmaceutics, 2021.
504			_aIncludes bibliographical references.
520	3		_aRenal allograft survival requires multiple immunosuppressive drugs. This strategy may lead to gastric complications that necessitate gastro-protective medications, notably, proton pump inhibitors (PPI). This study aimed to compare the influence of pantoprazole and esomeprazole on serum cyclosporine trough levels (C0) in renal transplant recipients (RTR). A prospective, parallel, open-label trial was conducted on 47 adult RTR receiving cyclosporine doses adjusted to attain trough concentrations of 100 to 150 μg/L, mycophenolate mofetil (MMF) 750 mg q12 hour and prednisolone at 5 mg daily at Nasser Institute, Cairo, Egypt from January to September 2016. Patients were randomized into the esomeprazole group (25) or pantoprazole group (22) receiving the same dose (40 mg once daily). The study outcomes included clinical signs of rejection and renal function decline, assessed by elevations in serum creatinine, caused by cyclosporine level variations in either of the two study groups. Renal function, C0 and CBC measurements were measured at baseline and monthly for 6 months. The mean C0 values were higher in the pantoprazole group than in the esomeprazole group in the sixth month only (P = .007). Serum creatinine level was lower in the sixth month than at baseline in the esomeprazole group (P = .004). There were no signs of rejection biochemical or clinical in any of the study groups. In conclusion, PPIs should be used with caution and doses should be titrated to reach the C0 targets in RTR, which is of more importance in pantoprazole than esomeprazole to avoid C0 level elevation or decline affecting the allograft function
546			_aText in English, abstracts in English and Arabic.
650		0	_aPharmaceutical industry
650		0	_aPharmaceutical technology
650		0	_aPharmacology
700	1		_aProf. Dr. Bendas, Ehab Rasmy. _esupervisor
700	1		_aProf. Dr. Basalious, Emad Bashir. _esupervisor
700	1		_aDr. Elbatanony, Rasha. _esupervisor
856	4	0	_3DSpace electronic resources _uhttp://repository.fue.edu.eg/xmlui/handle/123456789/5779
942			_cTHESIS
999			_c13031 _d13031