000			04047nam a22003617i 4500
999			_c13032 _d13032
008			220407s2022 ua a|||f bm|| 00| 0 eng d
040			_aEG-EULC _cEG-EULC _dEG-EULC _erda
041	0		_aeng _bara
082	0	4	_223 _a616.83 _bA.D.C
100	1		_aAbou El fadl, Dina Khaled Mohamed _eauthor.
245	1	2	_aA Clinical study on the impact of docosahexaenoic acid on the prevention of necrotizing enterocolitis in preterm neonates / _cBy Dina Khaled Mohamed Abou El fadl ; supervisors : prof. Nagwa Ali Saberi, prof. Ebtissam Abdel Ghaffar Darweesh, Dr. Marwa Adel Ahmed, Dr. Yasmin Aly Farid.
246	3	5	_aدراسة إكلينيكية عن تأثير حمض الدوكوساهيكسانويك فى الوقاية من إلتهاب الامعاء والقولون الناخر فى المبتسرين
264		0	_c2022.
300			_a134 pages : _billustrations (some color) ; _c24 cm
336			_2rdacontent _atext _btxt
337			_2rdamedia _aunmediated _bn
338			_2rdacarrier _avolume _bnc
500			_asupervisors : prof. Nagwa Ali Saberi, prof. Ebtissam Abdel Ghaffar Darweesh, Dr. Marwa Adel Ahmed, Dr. Yasmin Aly Farid.
502			_aThesis (Ph.D.)-Ain Shams university, Faculty of pharmacy, Department of Pharmacy practice and clinical pharmacy, 2022.
504			_aIncludes bibliographical references (95-123 p.)
520	3		_aPreterm neonates have under-developed immune-regulatory system; consequently, there is a risk for developing chronic inflammation. Necrotizing enterocolitis (NEC) is an acute devastating neonatal intestinal inflammatory disorder. Due to the obscure multifactorial etiology, early diagnosis and effective treatment of NEC are limited. Consequently, effective strategies in the prevention of NEC, including nutritional approaches, are critically needed. The current study was conducted to assess the potential immunomodulatory effect of Docosahexaenoic Acid (DHA) supplementation in preterm neonates at neonatal intensive care unit (NICU) and subsequently its effect on preventing or reducing NEC incidence. This was a prospective randomized controlled study. A total of 67 neonates, with gestational age equal or less than 32 weeks at birth and weight less than or equal 1500 g, were randomly assigned to either DHA group or the control group. Modified Bell’s staging criteria for NEC was used as an objective tool for diagnosis and staging of NEC. Levels of Interleukin 1 beta (IL-1β) were measured at baseline and after 10 days. Mortality and NICU length of stay (LOS) were also monitored. Thirty neonates of each group completed the study. A statistically significant difference was observed between the two groups regarding diagnosis and staging of NEC (p = 0.0001). There was also a statistically significant difference between DHA group 22(73.3), 95% CI [55.9, 86.5] and the control group 8 (26.7), 95% CI [13.5, 44.1] in the percentage change in IL-1β levels (p = 0.0001). A statistically significant association was found between IL and 1 β change and NEC diagnosis (p = 0.001). NICU LOS was significantly lower among DHA group 21.63 ± 6.67 compared to the control group 25.07 ± 4.67 (p = 0.025). Mortality n (%) among the control group 4 (11.8) was higher than DHA group 3 (9.1), however, no significant difference was detected (p = 1.0). Findings of this study suggest that enteral DHA supplementation can reduce NEC incidence in preterm neonates through its immunoregulatory effect that modulates production of regulatory cytokines.
546			_aText in English, abstracts in English and Arabic.
650		0	_aDocosahexaenoic acid.
650		0	_aDocosahexaenoic Acids.
650		0	_aHealth aspects.
650		0	_aphysiology.
700	1		_933919 _aSaberi, Nagwa Ali _esupervisor
700	1		_933920 _aDarweesh, Ebtissam Abdel Ghaffar _esupervisor
700	1		_933921 _aAhmed, Marwa Adel _esupervisor
700	1		_933922 _aFarid, Yasmin Aly _esupervisor
856	4	0	_3DSpace electronic resources _uhttp://repository.fue.edu.eg/xmlui/handle/123456789/6048
942			_cTHESIS