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| 008 | 220704s2022 ua a|||f bm|| 00| 0 eng d | ||
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_aeng _bara |
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_222 _a616.994061 _bA.M.D |
| 100 | 1 |
_aAbdelshaheed, Mennatallah Mahmoud _eauthor. |
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| 245 | 1 | 0 |
_aDesign, Synthesis and Biological Evaluation of New Fused Piperidine Analogues as Anticancer Agents / _cby Mennatallah Mahmoud Abdelshaheed Bachelor of Pharmacy (Clinical Pharmacy), (2016) Faculty of Pharmacy, Mansoura University ; Supervisors : Prof. Dr. Hussein I. El-Subbagh Professor of Medicinal Chemistry, Faculty of Pharmacy, Mansoura Universit, Prof. Dr. Khairia M. Youssef Professor of Pharmaceutical Chemistry, Faculty of Pharmacy, Future University in Egypt, Dr. Iten M. Fawzy Lecturer of Pharmaceutical Chemistry, Faculty of Pharmacy, Future University in Egypt. |
| 246 | 3 | 5 | _aتصميم و تشييد و تقييم بعض مشتقات البيبيريدين الجديدة كمضادات للسرطان |
| 264 | 0 | _c2022 | |
| 300 |
_a124 pages : _billustrations ; _c24 cm |
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| 336 |
_2rdacontent _atext _btxt |
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| 337 |
_2rdamedia _aunmediated _bn |
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| 338 |
_2rdacarrier _avolume _bnc |
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| 500 | _aSupervisors : Prof. Dr. Hussein I. El-Subbagh, Professor of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Prof. Dr. Khairia M. Youssef, Professor of Pharmaceutical Chemistry, Faculty of Pharmacy, Future University in Egypt, Dr. Iten M. Fawzy, Lecturer of Pharmaceutical Chemistry, Faculty of Pharmacy, Future University in Egypt. | ||
| 502 | _aThesis (M.Sc.)--Future University in Egypt, Faculty of pharmacy, Medicinal Chemistry, 2022. | ||
| 504 | _aIncludes bibliographical references (pages 104- 124). | ||
| 520 | 3 | _aCancer is a serious health problem and is one of the leading causes of death worldwide. Piperidine is an essential pharmacophore and a favoured scaffold in the field of drug design. Piperidine nucleus exhibited great potential in chemotherapy. Previous studies have reported the antiproliferative effect of piperidine moiety against different cancer cell lines. Piperidine was found to be able to cause tubulin inhibition and induce apoptosis and cell cycle arrest in various types of cancer cells. In this thesis four different series of piperidine derivatives inspired by Curcumin were designed, synthesised, and tested in vivo and in vitro for their antitumor effect. | |
| 546 | _aText in English, abstract in English and Arabic. | ||
| 650 | 0 |
_aCancer _xTreatment. |
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| 650 | 0 | _aAntineoplastic agents. | |
| 650 | 0 | _aMedicine. | |
| 700 | 1 |
_933951 _aEl-Subbagh, Hussein I. _esupervisor |
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| 700 | 1 |
_933952 _aYoussef, Khairia M. _esupervisor |
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| 700 | 1 |
_933953 _aFawzy, Iten M. _esupervisor |
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| 856 | 4 | 0 | _uhttp://repository.fue.edu.eg/xmlui/handle/123456789/6062 |
| 942 | _cTHESIS | ||