000			04387ntm a2200373 i 4500
001			12102116
005			20231211155539.0
008			150118s2023 ua a f bm 000 0 eng |
040			_aEG-EULC _cEG-EULC _erda
041	0		_aeng _bara
082	0	4	_a615.1 _bE.EI _222
100	1		_aElhefnawy, Esraa Akram Helmi, _eauthor. _934043
245	1	0	_aImplication of JAK/STAT Signaling Pathway on Acetic Acid-Induced Ulcerative Colitis in Rats / _cBy Esraa Akram Helmi Elhefnawy, (Bachelor’s Degree of Pharmacy, Faculty of Pharmacy, Future University in Egypt (2017), Teaching Assistant, Pharmacology, Toxicology & Biochemistry Department, Faculty of Pharmacy, Future University in Egypt, Under the Supervision of Dr. Hala Fahmy Zaki, Professor of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Dr. Nabila El-Maraghy, Professor of Pharmacology and Toxicology & Vice Dean of Community Services & Environmental Development, Faculty of Pharmacy, Future University in Egypt, Dr. Enas Abd El-Haleim, Assistant Professor of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University
246	1	5	_aمشاركة مسار إشارات جاك/ ستات في التهاب القولون المتقرح المحدث بحمض الخل في الجرذان
264		1	_c2023
300			_aIX, 142 pages, 5 pages : _billustrations (mostly color) ; _c22 cm
336			_2rdacontent _atext
337			_2rdamedia _aunmediated
338			_2rdacarrier _avolume
500			_aBy Esraa Akram Helmi Elhefnawy, (Bachelor’s Degree of Pharmacy, Faculty of Pharmacy, Future University in Egypt (2017), Teaching Assistant, Pharmacology, Toxicology & Biochemistry Department, Faculty of Pharmacy, Future University in Egypt, Under the Supervision of Dr. Hala Fahmy Zaki, Professor of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Dr. Nabila El-Maraghy, Professor of Pharmacology and Toxicology & Vice Dean of Community Services & Environmental Development, Faculty of Pharmacy, Future University in Egypt, Dr. Enas Abd El-Haleim, Assistant Professor of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University
502			_aThesis (M.Sc.)-Cairo University, Faculty of Pharmacy, Department of Pharmacology and Toxicology, 2023.
504			_aIncludes bibliographical references.
520	3		_aUlcerative Colitis (UC) is a chronic idiopathic inflammatory bowel disease in which the colon’s lining becomes inflamed. Exploring herbal remedies that can recover mucosal damage is becoming popular in UC. The study aims to investigate the probable colo-protective effect of a natural isoflavone, genistein (GEN), and/or sulfasalazine (SZ), against acetic acid (AA)-induced UC in rats, in addition to exploring the possible underlying mechanisms. UC was induced by the intrarectal instillation of 1-2 ml of 5% AA for 24 hours. AA-induced UC rats were allocated into the disease group and three treated groups, with SZ (100 mg/kg), GEN (100 mg/kg), and their combination for 14 days, besides the control groups. The anti-colitic efficacy of GEN and/or SZ was evidenced by hindering the AA-induced weight loss, colon edema, and macroscopic scores, besides reduced disease activity index and colon weight/length ratio. Furthermore, treatments attenuated the colon histopathological injury scores, increased the number of goblet cells, and decreased fibrosis. Both treatments reduced the up-regulation of INF-γ/JAK1/STAT1 and INF-γ /TLR-4/ NF-κB signaling pathways and modulated the IRF-1/iNOS/NO and IL-6/JAK2/STAT3/COX-2 pathways and consequently, reduced the levels of TNF-α and IL-1β. Moreover, both treatments diminished oxidative stress, by reducing the myeloperoxidase (MPO) level and elevating the superoxide dismutase (SOD) activity, and hindered apoptosis; proved by the decreased immunohistochemical expression of caspase-3. The current findings offer novel insights into the protective effects of GEN and suggest a superior benefit of combining GEN with SZ, over either drug alone, in the UC management.
546			_aText in English, abstracts in English and Arabic.
650		0	_aPharmacology
650		0	_aToxicology
650		0	_aUlcerative colitis
650		0	_aGenistein
650		0	_aSulfasalazine
650		0	_aAcetic acid
856	4	0	_3DSpace electronic resources
942			_cTHESIS _2ddc
999			_c13168 _d13168