000			03550nam a22003014i 4500
999			_c2088 _d2088
001			14390113
005			20190718131509.0
008			060525s2006 gw a f b 001 0 eng d
010			_a 2006928067
020			_a9783540256380 (alk. paper)
040			_aDLC _cDLC _erda
082	0	4	_222 _a615.19 _bD.
245	0	0	_aDrug discovery and evaluation : _bsafety and pharmacokinetic assays / _cH. Gerhard Vogel (ed.) ; Franz Jakob Hock , Jochen Maas , Dieter Mayer (co-editors).
264		1	_aBerlin ; _aNew York : _bSpringer, _cc2006.
300			_axxxi, 889 pages. : _bIllustrations ; _c28 cm
336			_2rdacontent _atext
337			_2rdamedia _aunmediated
338			_2rdacarrier _avolume
504			_aIncludes bibliographical references and index.
505	0		_aGeneral Introduction: Section I Safety Pharmacology: Introduction for Section I Safety Pharmacology.- Status of Safety Pharmacology and present Guidelines.- Central Nervous System Safety Pharmacology Studies.- Methods in Cardiovascular Safety Pharmacology.- Safety Pharmacology for Renal System Drugs.- Respiratory Function Assays in Safety Pharmacology.- Safety Tests in Metabolism Pharmacology.- Safety Pharmacology in Peripheral Nervous System Drugs.- Safety Pharmacology for Intravenous and Inhalation Anesthetics.- Side effects of central analgesic drugs.- Safety Pharmacology of Anti-inflammatory drugs.- Safety Pharmacology of Drugs with Osteoarthritis-related activity.- Safety Pharmacology of Blood Constituents.- Safety Assessment of Drugs Used in Ophthalmology.- Safety Assays in Endocrine Pharmacology.- Safety Assays in Skin Pharmacology.- Safety Pharmacology in Biologics.- Magnetic Resonance Imaging in Pharmaceutical Safety Assessment.- Perspectives of Safety Pharmacology, Ongoing Initiatives and Activities, Pharmaceuticals in the Environment.- Section II Safety Pharmacokinetics: Introduction.- Absorption-ex vivo tests.- Absorption-in vitro tests-cell based.- Absorption-in vitro tests-non cell based.- Absorption-in vivo tests (radiolabeled).- Bioanalytical assays-GC.- Bioanalytical assays-LC-MS/MS.- Bioanalytical assays-RIA/ELISA.- Bioanalytical assays-Toxicokinetics.- Clinical studies--typical designs.- Distribution-across barriers.- Distribution-in vitro tests-protein binding.- Distribution-in vivo-other methods.- Distribution-in vivo-perfused organs.- Distribution-in vivo-QWBA.- Drug-drug interaction-enzyme induction.- Drug-drug interaction-enzyme inhibition.- In-silico ADME Modeling.- Metabolism-enzyme mapping.- Metabolism-in vitro stability/profiling.- Metabolism-in vivo profiling.- Pharmacogenomics in DME.- Physicochemical properties.- Population kinetics.- Typical PK/PD approaches.- Section III Safety toxicology: Introduction.- International Guidelines.- General toxicity (acute, subchronic, chronic, carcinogenicity).- In silico methods.- Alternative methods for carcinogenicity testing.- Drug Addiction in monkeys.- Genotoxicity.- Pathology.- Reproductive Toxicology.- Toxicogenomics.- Toxicoproteomics
520			_aThis book is a landmark in the continuously changing world of drugs. It is essential reading for scientists and managers in the pharmaceutical industry who are involved in drug finding, drug development and decision making in the development process
650		0	_aPharmacology, Experimental.
650		0	_aDrugs _xDesign.
650		0	_aDrugs _xTesting.
700	1		_aVogel, H. Gerhard, _d1927- _98515 _eauthor.
856			_3Abstract _uhttp://repository.fue.edu.eg/xmlui/handle/123456789/1539
942			_cBK _2ddc