000			03234nam a22003494i 4500
999			_c2101 _d2101
001			12482068
005			20200923103648.0
008			010725s2001 enka f b 001 0 eng d
010			_a 2001272263
020			_a0198505337 (pbk.)
020			_a9780198505334
020			_a0195668863
020			_a9780195668865
040			_aDLC _cDLC _dDLC _erda
082	0	0	_a615.19 _221 _bP.G.I.
100	1		_aPatrick, Graham L. _98575 _eauthor.
245	1	3	_aAn introduction to medicinal chemistry / _cGraham L. Patrick.
250			_aSecond edition.
264		1	_aOxford ; _aNew York : _bOxford University Press, _c2001.
300			_axxiii, 622 pages : _billustrations ; _c25 cm
336			_2rdacontent _atext
337			_2rdamedia _aunmediated
338			_2rdacarrier _avolume
504			_aIncludes bibliographical references (p. [598]) and index.
505	0		_aDrugs and drug targets : an overview. Drug targets. Protein structure and function -- Enzymes : structure and function -- Receptors : structure and function -- Receptors and signal transduction -- Nucleic acids : structure and function -- Pharmacodynamics and pharmacokinetics. Enzymes as drug targets -- Receptors as drug targets -- Nucleic acids as drug targets -- Miscellaneous drug targets -- Pharmacokinetics and related topics -- Case study 1 : statins -- Drug discovery, design, and development. Drug discovery : finding a lead -- Drug design : optimizing target interactions -- Drug design : optimizing access to the target -- Getting the drug to market -- Case study 2 : the design of ACE inhibitors -- Case study 3 : artemisinin and related antimalarial drugs -- Case study 4 : the design of oxamniquine -- Tools of the trade. Combinatorial and parallel synthesis -- Computers in medicinal chemistry -- Quantitative structure-activity relationships (QSAR) -- Case study 5 : design of a thymidylate synthase inhibitor -- Selected topics in medicinal chemistry. Antibacterial agents -- Antiviral agents -- Anticancer agents -- Cholinergics, anticholinergics, and anticholinesterases -- Drugs acting on the adrenergic nervous system -- The opiod analgesics -- Anti-ulcer agents -- Cardiovascular drugs -- Case study 6 : steroidal anti-inflammatory agents -- Case study 7 : current research into antidepressant agents -- Case study 8 : the design and development of aliskiren -- Case study 9 : factor Xa inhibitors -- Case study 10 : reversible inhibitors of HCV NS3-4A protease -- Appendix 1 : essential amino acids -- Appendix 2 : the standard genetic code -- Appendix 3 : statistical data for QSAR -- Appendix 4 : the action of nerves -- Appendix 5 : microorganisms -- Appendix 6 : trade names and drugs -- Appendix 7 : hydrogen bonding interactions.
520			_aThis volume provides an introduction to medicinal chemistry. It covers basic principles and background, and describes the general tactics and strategies involved in developing an effective drug
650		0	_aPharmaceutical chemistry.
856	4	1	_3Table of contents only _uhttp://www.loc.gov/catdir/enhancements/fy0611/2001272263-t.html
856	4	2	_3Publisher description _uhttp://www.loc.gov/catdir/enhancements/fy0611/2001272263-d.html
942			_cBK _2ddc