000 03493cam a22003854a 4500
999 _c5219
_d5219
001 14974873
005 20190509120406.0
008 070820s2008 nyua b 001 0 eng
010 _a 2007034623
020 _a9780849375934 (hb : alk. paper)
020 _a0849375932 (hb : alk. paper)
040 _aDNLM/DLC
_cDLC
_dNLM
_dBTCTA
_dBAKER
_dYDXCP
_dC#P
_dMUQ
_dIXA
_dDLC
_erda
050 0 0 _aRM302
_b.D784 2008
082 0 0 _a615.7045
_222
_bD
245 0 0 _aDrug-drug interactions /
_cedited by A. David Rodrigues.
250 _a2nd ed.
260 _aNew York :
_bInforma Healthcare,
_cc2008.
300 _axi. 744 p. :
_bill. ;
_c24 cm.
336 _2rdacontent
_atext
337 _2rdamedia
_aunmediated
338 _2rdacarrier
_avolume
490 1 _aDrugs and the pharmaceutical sciences ;
_v179
504 _aIncludes bibliographical references and index.
505 0 _aIntroducing pharmacokinetic and pharmacodynamic concepts / Malcolm Rowland -- In vitro enzyme kinetics applied to drug-metabolizing enzymes / Kenneth R. Korzekwa -- Human cytochromes P450 and their role in metabolism-based drug-drug interactions / Stephen E. Clarke and Barry C. Jones -- UDP-glucuronosyltransferases / Rory P. Remmel, Jin Zhou, and Upendra A. Argikar -- Drug-drug interactions involving the membrane transport process / Hiroyuki Kusuhara and Yuichi Sugiyama -- In vitro models for studying induction of cytochrome P450 enzymes / Jose M. Silva and Deborah A. Nicoll-Griffith -- In vitro approaches for studying the inhibition of drug-metabolizing enzymes and identifying the drug-metabolizing enzymes responsible for the metabolism of drugs (reaction phenotyping) with emphasis on cytochrome P450 / Brian W. Ogilvie ... [et al.] -- The role of P-glycoprotein in drug disposition: significance to drug development / Matthew D. Troutman ... [et al.] -- Cytochrome P450 protein modeling and ligand docking / K. Anton Feenstra, Chris de Graaf, and Nico P.E. Vermeulen -- Role of the gut mucosa in metabolically based drug-drug interactions / Kenneth E. Thummel, Danny D. Shen, and Nina Isoherannen -- Mechanism-based inhibition of human cytochromes P450: in vitro kinetics and in vitro-in vivo correlations / Xin Zhang, David R. Jones, and Stephen D. Hall -- Transporter-mediated drug interactions: molecular mechanisms and clinical implications / Jiunn H. Lin -- Metabolism and transport drug interaction database: a web-based research and analysis tool / Houda Hachad, Isabelle Ragueneau-Majlessi, and René H. Levy -- In vivo probes for studying induction and inhibition of cytochrome P450 enzymes in humans / Grant R. Wilkinson -- Drug-drug interactions: clinical perspective / David J. Greenblatt and Lisa L. von Moltke -- An integrated approach to assessing drug-drug interactions: a regulatory perspective / Shiew-Mei Huang, Lawrence J. Lesko, and Robert Temple -- Drug-drug interactions: toxicological perspectives / Sidney D. Nelson -- Drug-drug interactions: marketing perspectives / Kevin J. Petty and Jose M. Vega.
650 0 _aDrug interactions.
_924456
650 0 _aPharmacokinetics.
_924457
650 1 2 _aDrug Interactions.
_924458
650 2 2 _aPharmaceutical Preparations
_xmetabolism.
_924459
650 2 2 _aPharmacokinetics.
_924460
700 1 _aRodrigues, A. David.
_924461
830 0 _aDrugs and the pharmaceutical sciences ;
_vv. 179.
_924462
856 _3Abstract
_uhttp://repository.fue.edu.eg/xmlui/handle/123456789/1604
942 _cBK
_2ddc