000			03349cam a22003374a 4500
999			_c6827 _d6827
001			15807210
005			20190912142949.0
008			090708s2009 gw a b 001 0 eng c
010			_a 2009464260
020			_a9783527323302 (pbk.)
020			_a3527323309 (pbk.)
040			_aUKM _cUKM _dYDXCP _dOHX _dBWX _dBTCTA _dIXA _dTXA _dDLC _erda
050	0	0	_aQD415 _b.C456 2009
082	0	4	_221 _a547 _bC
245	0	0	_aChemical biology : _blearning through case studies / _cedited by Herbert Waldmann and Petra Janning.
260			_aWeinheim : _bWiley-VCH, _cc2009.
300			_axxxiii, 271 p. : _bill. (some col.) ; _c25 cm.
336			_2rdacontent _atext
337			_2rdamedia _aunmediated
338			_2rdacarrier _avolume
504			_aIncludes bibliographical references and index.
505	0		_aYeast-based chemical genomic approaches / Katja Hubel -- Microarray-based strategies to identify unknown protein / Sabine Borgmann and Christof M. Niemeyer -- Compound collection synthesis for chemical biology / Kamal Kumar -- Target identification and validation of a WNT/P-catenin pathway modulator / Petra Janning -- Activity-based protein profiling of cys proteases / Renier van der Hoorn -- The use of photoaffinity labeling for the identification of the binding site of the antibiotic linezolid / Rolf Breinbauer and Matthias Mentel -- Surgical strikes : uses of analog sensitive technologies to target kinases of interest / Matthias Rabiller and Daniel Rauh -- Modulation of protein-protein interactions by small molecules / Stefanie Bovens and Christian Ottmann -- Targeted protein degradation in live cells / Markus Kaiser -- Trapoxin B : from total synthesis to epigenetics / Bruno Bulic -- Native chemical ligation : a tool for chemical protein synthesis / Christian F.W. Becker -- Using split inteins to prepare semi-synthetic proteins and to study the mechanism of protein trans-splicing / Henning D. Mootz -- Elucidation of the ras cycle with semi-synthetic proteins / Luc Brunsveld -- The study of rab GTpase recycling using semi-synthetic prenylated proteins / Kirill Alexandrov ... [et al.] -- Development of a model cancer vaccine candidate based on the MUC1 cellular surface glycopeptide epitope / Christian Hedberg and Ulrika Westerlind -- The introduction of chemical reporter groups by bioorthogonal ligation reactions for the imaging of cell-surface glycans / Rolf Breinbauer and Matthias Mental -- Sequence specific DNA-binding small molecules for protein recruitment and modulation of transcription / Hans-Dieter Arndt and Sascha Baumann -- G-quadruplex ligands as tools for elucidating c-MYC transcriptional regulation / Barbara Sacca and Markus Kaiser
520			_aThis first book to adopt a problem-based approach teaches the true basics of the subject through illustrated everyday case studies. The editor's extensive experience in writing textbooks and his close relationship to the authors ensure that the contributions are presented in a pedagogically uniform and highly motivating fashion
650		0	_aBiochemistry _xExperiments. _933211
650		0	_aBioactive compounds _xSynthesis. _933212
650		0	_aCombinatorial chemistry. _98465
700	1		_aWaldmann, H. _q(Herbert) _933213
700			_aJanning, Petra, _933214 _d1967-, _eeditor.
942			_cBK _2ddc