000 02530nam a22003497a 4500
005 20150311102719.0
008 150222s2005 nyua|||| b||| 001 0 eng d
020 _a9781259011115
020 _a007160393X
040 _d0
082 0 4 _222
_a615.7
_bS.L.A
100 1 _aShargel, Leon,
_d1941-
245 1 _aApplied biopharmaceutics & pharmacokinetics /
_cLeon Shargel, Susanna Wu-Pong, Andrew B.C. Yu.
246 3 _aApplied biopharmaceutics and pharmacokinetics.
250 _a5th ed.
260 _aNew York ,
_aLondon :
_bMcGraw-Hill,
_c2005.
300 _axx, 811 p. :
_bill. ;
_c24 cm.
336 _2rdacontent
_atext
337 _2rdamedia
_aunmediated
338 _2rdacarrier
_avolume
500 _aFormerly CIP. |5 Uk
500 _apharmacy bookfair2015
504 _aIncludes bibliographical references and index.
505 0 _aIntroduction to biopharmaceutics and pharmacokinetics -- Mathematic fundamentals in pharmacokinetics -- One-compartment open model: intravenous bolus administration -- Multicompartmental models : intravenous bolus administration -- Intravenous infusion -- Drug elimination and clearance -- Pharmacokinetics of oral absorption -- Multiple-dosage regimens -- Nonlinear pharmacokinetics -- Physiologic drug distribution and protein binding -- Drug elimination and hepatic clearance -- Pharmacogenetics -- Physiologic factors related to drug absorption -- Biopharmaceutic considerations in drug product design and in vitro drug product performance -- Drug product performance, in vivo : bioavailability and bioequivalence -- Impact of drug product quality and biopharmaceutics on clinical efficacy -- Modified-release drug products -- Targeted drug delivery systems and biotechnology products -- Relationship between pharmacokinetics and pharmacodynamics -- Application of pharmacokinetics to clinical situations -- Dosage adjustment in renal and hepatic disease -- Physiologic pharmacokinetic models, mean residence time, and statistical moment theory.
520 _aA textbook on the theoretical and practical applications of biopharmaceutics and pharmacokinetics. It provides you with a basic understanding of the principles of biopharmaceutics and pharmacokinetics and applies these principles to drug product development, drug product performance and drug therapy.
650 0 _aBiopharmaceutics.
650 0 _aPharmacokinetics.
650 2 2 _aModels, Chemical.
700 1 _aWu-Pong, Susanna.
700 1 _aYu, Andrew B. C.,
_d1945-
942 _2ddc
_cBK
999 _c9317
_d9317