Bioinformatics for beginners : genes, genomes, molecular evolution, databases and analytical tools /
Choudhuri, Supratim,
Bioinformatics for beginners : genes, genomes, molecular evolution, databases and analytical tools / Supratim Choudhuri, with contribution from Dr. Michael Kotewicz on the optical mapping of DNA, Center for food Safety and Applied Nutrition, FDA, College Park, Maryland. - xi, 225 pages : illustrations (some color) ; 29 cm
pharmacy bookfair2016
Includes bibliographical references and index.
Front Cover; Bioinformatics for beginners; Copyright Page;
Contents; Preface; Acknowledgment; 1 Fundamentals of Genes
and Genomes; 1.1 Biological Macromolecules, Genomics, and
Bioinformatics; 1.2 DNA as the Universal Genetic Material;
1.3 DNA Double Helix; 1.3.1 Structural Units of DNA; 1.3.2
Linkage between Nucleotides; 1.3.3 Base-Pairing Rules,
Double Helix, and Triple Helix; 1.3.4 Single-Stranded DNA;
1.3.5 Base Sequence and the Genetic Code; 1.4
Conformations of DNA; 1.5 Typical Eukaryotic Gene
Structure; 1.5.1 Transcribed Region; 1.5.1.1 Intron-
Splicing Signals.
1.5.1.2 Effect of Intron Phase on Alternative
Splicing1.5.1.3 Evolution of Introns; 1.5.2 52 Flanking
Region of Transcribed Genes; 1.5.3 32 Flanking Region of
Transcribed Genes; 1.6 Mutations in the DNA Sequence; 1.7
Some Features of RNA; 1.7.1 Instability of mRNA; 1.7.2 52
and 32 Untranslated Regions of mRNA; 1.7.3 Secondary
Structures in RNA; 1.8 Coding Versus Noncoding RNA; 1.8.1
Small Noncoding RNA, Long Noncoding RNA, Competing
Endogenous RNA, and Circular RNA; 1.9 Protein Structure
and Function; 1.9.1 Configuration and Chirality of Amino
Acids; 1.9.2 Ionic Character of Amino Acids.
1.9.3 Relationship between Protein Function and the
Location of Amino Acids in the Polypeptide Chain1.9.4
Linkage between Amino Acids-The Peptide Bond; 1.9.5 Four
Levels of Protein Structure; 1.9.6 Acidic and Basic
Proteins; 1.9.7 Nonstandard Amino Acids in Polypeptide
Chains; 1.10 Genome Structure and Organization; 1.10.1 The
Structure of a Representative Genome-The Human Genome;
1.10.2 Functional Sequence Elements in the Genome;
1.10.2.1 Promoters; 1.10.2.2 Enhancers; 1.10.2.3 Locus
Control Regions; 1.10.2.4 Insulators.
1.10.3 Epigenetic Modifications of the Genome Can Edit the
Language Written in the DNA Sequence and Add an Extra
Layer of C ... 1.10.3.1 Histone Code; 1.10.3.2 The
Dynamics of Epigenetic Changes; 1.10.4 Lessons Learned
from the Second Phase of the ENCODE Project about the DNA
Elements in the Human Genome and its Epige ... ;
References; 2 Fundamentals of Molecular Evolution; 2.1
Bioinformatics, Molecular Evolution, and Phylogenetics;
2.2 Biological Evolution and Basic Premises of Darwinism;
2.2.1 First Experimental Demonstration of Evolutionary
Principles in the Test Tube.
2.3 Molecular Basis of Heritable Genetic Variations-The
Raw Materials for Evolution2.3.1 Molecular Basis of
Mutation; 2.3.2 Recombination and Generation of Genetic
Diversity; 2.3.3 Gene Flow and Introduction of Genetic
Diversity; 2.3.4 Origin of New Genes, Creation of Genetic
Diversity and Genome Evolution; 2.3.4.1 Origin of New
Genes from Coding Sequences (Pre-existing Genes);
2.3.4.1.a Gene Duplication and the 2R Hypothesis;
2.3.4.1.b Exon Shuffling; 2.3.4.1.c Gene Fusion and
Fission; 2.3.4.1.d Horizontal Gene Transfer; 2.3.4.2
Origin (de Novo) of New Genes from Noncoding Sequences.
Bioinformatics for Beginners provides a coherent and
friendly treatment of bioinformatics for any student or
scientist within biology who has not routinely performed
bioinformatic analysis. The book discusses relevant
principles needed to understand the theoretical
underpinnings of bioinformatic analysis, and demonstrates
with examples targeted analysis using freely available web
-based software and publicly available databases.
Eschewing non-essential information, the work focuses on
principles and hands-on analysis and points to many
further study options.
9780124104716 0124104711
2014497397
101636996 DNLM
Computational biology.
Computational biology--Methods.
Computational Biology.
QH324.2 / .C438 2014
570.285 / C.S.B
2014 H-918 QU 26.5
Bioinformatics for beginners : genes, genomes, molecular evolution, databases and analytical tools / Supratim Choudhuri, with contribution from Dr. Michael Kotewicz on the optical mapping of DNA, Center for food Safety and Applied Nutrition, FDA, College Park, Maryland. - xi, 225 pages : illustrations (some color) ; 29 cm
pharmacy bookfair2016
Includes bibliographical references and index.
Front Cover; Bioinformatics for beginners; Copyright Page;
Contents; Preface; Acknowledgment; 1 Fundamentals of Genes
and Genomes; 1.1 Biological Macromolecules, Genomics, and
Bioinformatics; 1.2 DNA as the Universal Genetic Material;
1.3 DNA Double Helix; 1.3.1 Structural Units of DNA; 1.3.2
Linkage between Nucleotides; 1.3.3 Base-Pairing Rules,
Double Helix, and Triple Helix; 1.3.4 Single-Stranded DNA;
1.3.5 Base Sequence and the Genetic Code; 1.4
Conformations of DNA; 1.5 Typical Eukaryotic Gene
Structure; 1.5.1 Transcribed Region; 1.5.1.1 Intron-
Splicing Signals.
1.5.1.2 Effect of Intron Phase on Alternative
Splicing1.5.1.3 Evolution of Introns; 1.5.2 52 Flanking
Region of Transcribed Genes; 1.5.3 32 Flanking Region of
Transcribed Genes; 1.6 Mutations in the DNA Sequence; 1.7
Some Features of RNA; 1.7.1 Instability of mRNA; 1.7.2 52
and 32 Untranslated Regions of mRNA; 1.7.3 Secondary
Structures in RNA; 1.8 Coding Versus Noncoding RNA; 1.8.1
Small Noncoding RNA, Long Noncoding RNA, Competing
Endogenous RNA, and Circular RNA; 1.9 Protein Structure
and Function; 1.9.1 Configuration and Chirality of Amino
Acids; 1.9.2 Ionic Character of Amino Acids.
1.9.3 Relationship between Protein Function and the
Location of Amino Acids in the Polypeptide Chain1.9.4
Linkage between Amino Acids-The Peptide Bond; 1.9.5 Four
Levels of Protein Structure; 1.9.6 Acidic and Basic
Proteins; 1.9.7 Nonstandard Amino Acids in Polypeptide
Chains; 1.10 Genome Structure and Organization; 1.10.1 The
Structure of a Representative Genome-The Human Genome;
1.10.2 Functional Sequence Elements in the Genome;
1.10.2.1 Promoters; 1.10.2.2 Enhancers; 1.10.2.3 Locus
Control Regions; 1.10.2.4 Insulators.
1.10.3 Epigenetic Modifications of the Genome Can Edit the
Language Written in the DNA Sequence and Add an Extra
Layer of C ... 1.10.3.1 Histone Code; 1.10.3.2 The
Dynamics of Epigenetic Changes; 1.10.4 Lessons Learned
from the Second Phase of the ENCODE Project about the DNA
Elements in the Human Genome and its Epige ... ;
References; 2 Fundamentals of Molecular Evolution; 2.1
Bioinformatics, Molecular Evolution, and Phylogenetics;
2.2 Biological Evolution and Basic Premises of Darwinism;
2.2.1 First Experimental Demonstration of Evolutionary
Principles in the Test Tube.
2.3 Molecular Basis of Heritable Genetic Variations-The
Raw Materials for Evolution2.3.1 Molecular Basis of
Mutation; 2.3.2 Recombination and Generation of Genetic
Diversity; 2.3.3 Gene Flow and Introduction of Genetic
Diversity; 2.3.4 Origin of New Genes, Creation of Genetic
Diversity and Genome Evolution; 2.3.4.1 Origin of New
Genes from Coding Sequences (Pre-existing Genes);
2.3.4.1.a Gene Duplication and the 2R Hypothesis;
2.3.4.1.b Exon Shuffling; 2.3.4.1.c Gene Fusion and
Fission; 2.3.4.1.d Horizontal Gene Transfer; 2.3.4.2
Origin (de Novo) of New Genes from Noncoding Sequences.
Bioinformatics for Beginners provides a coherent and
friendly treatment of bioinformatics for any student or
scientist within biology who has not routinely performed
bioinformatic analysis. The book discusses relevant
principles needed to understand the theoretical
underpinnings of bioinformatic analysis, and demonstrates
with examples targeted analysis using freely available web
-based software and publicly available databases.
Eschewing non-essential information, the work focuses on
principles and hands-on analysis and points to many
further study options.
9780124104716 0124104711
2014497397
101636996 DNLM
Computational biology.
Computational biology--Methods.
Computational Biology.
QH324.2 / .C438 2014
570.285 / C.S.B
2014 H-918 QU 26.5