Study of the effect of lubricants on the physicochemical properties of certain polymeric films /
Fouly, Aya Mohamed Adel Abdel Halim.
Study of the effect of lubricants on the physicochemical properties of certain polymeric films / دراسة عن تاثير موانع الالتصاق على الخواص Aya Mohamed Adel Abdel Halim Fouly ; Supervisors Hussein Ammar, Mamdouh Ghorab, Shadid Gad Abdulrahman. - 306 pages : illustrations ; 24 cm.
Supervisor : Hussein Amaar.
Thesis (M.Sc)-Suez Canal university, Faculty of pharmacy, Department of Pharmaceutics, 2014.
Includes bibliographical references.
Solid dosage forms represent a great share of the pharmaceutical production due
to being; stable, easier for shipping and handling and have longer expiration
dates. In addition, solid dosage forms require less shelf space, do not require
preservation and have accurate dosage (single dose).
Coating represents a very important operation during the production of solid
dosage forms either due to enhancing tablet flowability and line clearance or due
to functional and patient adherence related issues.
Polymeric film coating is CHARacterized over other coating methodologies by its
quality, operational efficiency, safety and profit. Aqueous-based systems have
gained popularity over solvent-based systems due to their lower toxicity levels
and environment friendly standpoint.
Eudragit® acrylic resins have been widely used in the pharmaceutical industry,
they are CHARacterized by being water insoluble but swellable polymers.
Antiadherents are very common additives during aqueous acrylic polymeric
film coating so as to avoid susceptible stickiness or tackiness of polymeric films
which is a concern during both coating process and storage.
Talc is considered to be one of the most frequently used antiadherents specially
in the Egyptian market due to its low price and is CHARacterized by its
hydrophobic nature, Glyceryl monostearate (GMS) has been used as an
alternative for talc and is known by its waxy nature. The ready-to-use
PlasacrylTM T20 suspension which contains GMS as an antiadherent, triethyl
Abstract
ii
citrate as a plasticizer and polysorbate 80 as a surfactant has been recently used
with Eudragit® polymers.
In spite of being a corner stone in the treatment of the unwanted tablet
agglomeration during coating, antiadherents may be causative factor for many
changes in either the physicochemical properties or the dissolution properties of
acrylic polymeric film coating systems.
Polymer films must be mechanically strong such that they do not break or
fracture during processing, packaging, shipping, and storage.
Generally, particles coated with a film behave differently from the film itself.
However, there is no doubt that studies conducted on free films help to
understand the behavior of dosage forms coated with these films. Free films can
be obtained by the casting method, where a polymeric solution or dispersion is
cast onto a n
Text in English, abstracts in English and Arabic.
Pharmaceutics
Polymers in medicine.
Polymers
Biomedical materials
615.19 / F.A.S
Study of the effect of lubricants on the physicochemical properties of certain polymeric films / دراسة عن تاثير موانع الالتصاق على الخواص Aya Mohamed Adel Abdel Halim Fouly ; Supervisors Hussein Ammar, Mamdouh Ghorab, Shadid Gad Abdulrahman. - 306 pages : illustrations ; 24 cm.
Supervisor : Hussein Amaar.
Thesis (M.Sc)-Suez Canal university, Faculty of pharmacy, Department of Pharmaceutics, 2014.
Includes bibliographical references.
Solid dosage forms represent a great share of the pharmaceutical production due
to being; stable, easier for shipping and handling and have longer expiration
dates. In addition, solid dosage forms require less shelf space, do not require
preservation and have accurate dosage (single dose).
Coating represents a very important operation during the production of solid
dosage forms either due to enhancing tablet flowability and line clearance or due
to functional and patient adherence related issues.
Polymeric film coating is CHARacterized over other coating methodologies by its
quality, operational efficiency, safety and profit. Aqueous-based systems have
gained popularity over solvent-based systems due to their lower toxicity levels
and environment friendly standpoint.
Eudragit® acrylic resins have been widely used in the pharmaceutical industry,
they are CHARacterized by being water insoluble but swellable polymers.
Antiadherents are very common additives during aqueous acrylic polymeric
film coating so as to avoid susceptible stickiness or tackiness of polymeric films
which is a concern during both coating process and storage.
Talc is considered to be one of the most frequently used antiadherents specially
in the Egyptian market due to its low price and is CHARacterized by its
hydrophobic nature, Glyceryl monostearate (GMS) has been used as an
alternative for talc and is known by its waxy nature. The ready-to-use
PlasacrylTM T20 suspension which contains GMS as an antiadherent, triethyl
Abstract
ii
citrate as a plasticizer and polysorbate 80 as a surfactant has been recently used
with Eudragit® polymers.
In spite of being a corner stone in the treatment of the unwanted tablet
agglomeration during coating, antiadherents may be causative factor for many
changes in either the physicochemical properties or the dissolution properties of
acrylic polymeric film coating systems.
Polymer films must be mechanically strong such that they do not break or
fracture during processing, packaging, shipping, and storage.
Generally, particles coated with a film behave differently from the film itself.
However, there is no doubt that studies conducted on free films help to
understand the behavior of dosage forms coated with these films. Free films can
be obtained by the casting method, where a polymeric solution or dispersion is
cast onto a n
Text in English, abstracts in English and Arabic.
Pharmaceutics
Polymers in medicine.
Polymers
Biomedical materials
615.19 / F.A.S