Study of the effect of lubricants on the physicochemical properties of certain polymeric films / Aya Mohamed Adel Abdel Halim Fouly ; Supervisors Hussein Ammar, Mamdouh Ghorab, Shadid Gad Abdulrahman.

By:

Fouly, Aya Mohamed Adel Abdel Halim [author]

Contributor(s):

Material type: Text

TextLanguage: English Summary language: Arabic Publisher: 2014Description: 306 pages : illustrations ; 24 cmContent type:

text

Media type:

unmediated

Carrier type:

volume

Other title:

دراسة عن تاثير موانع الالتصاق على الخواص

Subject(s):

DDC classification:

615.19 F.A.S 21

Dissertation note: Thesis (M.Sc)-Suez Canal university, Faculty of pharmacy, Department of Pharmaceutics, 2014. Summary: Solid dosage forms represent a great share of the pharmaceutical production due to being; stable, easier for shipping and handling and have longer expiration dates. In addition, solid dosage forms require less shelf space, do not require preservation and have accurate dosage (single dose). Coating represents a very important operation during the production of solid dosage forms either due to enhancing tablet flowability and line clearance or due to functional and patient adherence related issues. Polymeric film coating is CHARacterized over other coating methodologies by its quality, operational efficiency, safety and profit. Aqueous-based systems have gained popularity over solvent-based systems due to their lower toxicity levels and environment friendly standpoint. Eudragit® acrylic resins have been widely used in the pharmaceutical industry, they are CHARacterized by being water insoluble but swellable polymers. Antiadherents are very common additives during aqueous acrylic polymeric film coating so as to avoid susceptible stickiness or tackiness of polymeric films which is a concern during both coating process and storage. Talc is considered to be one of the most frequently used antiadherents specially in the Egyptian market due to its low price and is CHARacterized by its hydrophobic nature, Glyceryl monostearate (GMS) has been used as an alternative for talc and is known by its waxy nature. The ready-to-use PlasacrylTM T20 suspension which contains GMS as an antiadherent, triethyl Abstract ii citrate as a plasticizer and polysorbate 80 as a surfactant has been recently used with Eudragit® polymers. In spite of being a corner stone in the treatment of the unwanted tablet agglomeration during coating, antiadherents may be causative factor for many changes in either the physicochemical properties or the dissolution properties of acrylic polymeric film coating systems. Polymer films must be mechanically strong such that they do not break or fracture during processing, packaging, shipping, and storage. Generally, particles coated with a film behave differently from the film itself. However, there is no doubt that studies conducted on free films help to understand the behavior of dosage forms coated with these films. Free films can be obtained by the casting method, where a polymeric solution or dispersion is cast onto a n

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Holdings
Item type	Current library	Collection	Call number	Copy number	Status	Date due	Barcode
Thesis	Main library C3 THESIES	Pharmacy ( Pharmaceutical Technology )	615.19 F.A.S (Browse shelf(Opens below))	1	Not for loan		00013960
Thesis	Main library C3 THESIES	Pharmacy ( Pharmaceutical Technology )	615.19 F.A.S (Browse shelf(Opens below))	2	Not for loan		00016464

Supervisor : Hussein Amaar.

Thesis (M.Sc)-Suez Canal university, Faculty of pharmacy, Department of Pharmaceutics, 2014.

Includes bibliographical references.

Solid dosage forms represent a great share of the pharmaceutical production due to being; stable, easier for shipping and handling and have longer expiration dates. In addition, solid dosage forms require less shelf space, do not require preservation and have accurate dosage (single dose). Coating represents a very important operation during the production of solid dosage forms either due to enhancing tablet flowability and line clearance or due to functional and patient adherence related issues. Polymeric film coating is CHARacterized over other coating methodologies by its quality, operational efficiency, safety and profit. Aqueous-based systems have gained popularity over solvent-based systems due to their lower toxicity levels and environment friendly standpoint. Eudragit® acrylic resins have been widely used in the pharmaceutical industry, they are CHARacterized by being water insoluble but swellable polymers. Antiadherents are very common additives during aqueous acrylic polymeric film coating so as to avoid susceptible stickiness or tackiness of polymeric films which is a concern during both coating process and storage. Talc is considered to be one of the most frequently used antiadherents specially in the Egyptian market due to its low price and is CHARacterized by its hydrophobic nature, Glyceryl monostearate (GMS) has been used as an alternative for talc and is known by its waxy nature. The ready-to-use PlasacrylTM T20 suspension which contains GMS as an antiadherent, triethyl Abstract ii citrate as a plasticizer and polysorbate 80 as a surfactant has been recently used with Eudragit® polymers. In spite of being a corner stone in the treatment of the unwanted tablet agglomeration during coating, antiadherents may be causative factor for many changes in either the physicochemical properties or the dissolution properties of acrylic polymeric film coating systems. Polymer films must be mechanically strong such that they do not break or fracture during processing, packaging, shipping, and storage. Generally, particles coated with a film behave differently from the film itself. However, there is no doubt that studies conducted on free films help to understand the behavior of dosage forms coated with these films. Free films can be obtained by the casting method, where a polymeric solution or dispersion is cast onto a n

Text in English, abstracts in English and Arabic.

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