Endotoxins : pyrogens, LAL testing, and depyrogenation /
Williams, Kevin L
Endotoxins : pyrogens, LAL testing, and depyrogenation / Kevin L. Williams ; with contributions by Karen Roberts, N. Anthony Nnalue - Second edition, revised and expanded - x, 372 pages : illustrations ; 24 cm - Drugs and the pharmaceutical sciences ; v. 111 .
1st ed. was published as Pyrogens: endotoxins and LAL testing and depyrogenation, by F. C. Pearson
Includes bibliographical references and index
Historical foundations of pyrogen research; pyrogen, endotoxin, and fever - an overview; endotoxin structure, function, activity; the host response to endotoxin; non-endotoxin microbial pyrogens (lesser endotoxins and superantigens); non-microbial exogenous pyrogens and drug fever; pharmaceutical manufacturing contamination control; endotoxin as a standard; the rabbit pyrogen test; LAL discovery, mechanism, and application; LAL assay development, validation and regulation.
This study describes the environmental presence, detection, properties and biological structure and function of endotoxins in parenteral manufacturing. It includes chapters on asay development, automation, depyrogenation, and regulation of testing by LAL methods.
0824793625 (alk. paper)
2002275620
Endotoxins--Analysis
Pyrogens--Analysis
Limulus test
Drugs--Microbiology
Endotoxins--analysis
Infusions, Parenteral--standards
Limulus Test
Pyrogens--analysis
QP632.E4 / P43 2001
616.01 / W.K.E
Endotoxins : pyrogens, LAL testing, and depyrogenation / Kevin L. Williams ; with contributions by Karen Roberts, N. Anthony Nnalue - Second edition, revised and expanded - x, 372 pages : illustrations ; 24 cm - Drugs and the pharmaceutical sciences ; v. 111 .
1st ed. was published as Pyrogens: endotoxins and LAL testing and depyrogenation, by F. C. Pearson
Includes bibliographical references and index
Historical foundations of pyrogen research; pyrogen, endotoxin, and fever - an overview; endotoxin structure, function, activity; the host response to endotoxin; non-endotoxin microbial pyrogens (lesser endotoxins and superantigens); non-microbial exogenous pyrogens and drug fever; pharmaceutical manufacturing contamination control; endotoxin as a standard; the rabbit pyrogen test; LAL discovery, mechanism, and application; LAL assay development, validation and regulation.
This study describes the environmental presence, detection, properties and biological structure and function of endotoxins in parenteral manufacturing. It includes chapters on asay development, automation, depyrogenation, and regulation of testing by LAL methods.
0824793625 (alk. paper)
2002275620
Endotoxins--Analysis
Pyrogens--Analysis
Limulus test
Drugs--Microbiology
Endotoxins--analysis
Infusions, Parenteral--standards
Limulus Test
Pyrogens--analysis
QP632.E4 / P43 2001
616.01 / W.K.E