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Endotoxins : pyrogens, LAL testing, and depyrogenation / Kevin L. Williams ; with contributions by Karen Roberts, N. Anthony Nnalue

By: Contributor(s): Material type: TextTextSeries: Drugs and the pharmaceutical sciences ; v. 111Publisher: New York : Marcel Dekker, [2001]Copyright date: ©2001 Edition: Second edition, revised and expandedDescription: x, 372 pages : illustrations ; 24 cmContent type:
  • text
Media type:
  • unmediated
Carrier type:
  • volume
ISBN:
  • 0824793625
Subject(s): DDC classification:
  • 23 616.01 W.K.E
LOC classification:
  • QP632.E4 P43 2001
Contents:
Historical foundations of pyrogen research; pyrogen, endotoxin, and fever - an overview; endotoxin structure, function, activity; the host response to endotoxin; non-endotoxin microbial pyrogens (lesser endotoxins and superantigens); non-microbial exogenous pyrogens and drug fever; pharmaceutical manufacturing contamination control; endotoxin as a standard; the rabbit pyrogen test; LAL discovery, mechanism, and application; LAL assay development, validation and regulation.
Summary: This study describes the environmental presence, detection, properties and biological structure and function of endotoxins in parenteral manufacturing. It includes chapters on asay development, automation, depyrogenation, and regulation of testing by LAL methods.
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Holdings
Item type Current library Collection Call number Copy number Status Date due Barcode
Books Books Main library A11 Pharmacy ( Microbiology ) 616.01 W.K.E (Browse shelf(Opens below)) 1 Available 00016313

1st ed. was published as Pyrogens: endotoxins and LAL testing and depyrogenation, by F. C. Pearson

Includes bibliographical references and index

Historical foundations of pyrogen research; pyrogen, endotoxin, and fever - an overview; endotoxin structure, function, activity; the host response to endotoxin; non-endotoxin microbial pyrogens (lesser endotoxins and superantigens); non-microbial exogenous pyrogens and drug fever; pharmaceutical manufacturing contamination control; endotoxin as a standard; the rabbit pyrogen test; LAL discovery, mechanism, and application; LAL assay development, validation and regulation.

This study describes the environmental presence, detection, properties and biological structure and function of endotoxins in parenteral manufacturing. It includes chapters on asay development, automation, depyrogenation, and regulation of testing by LAL methods.

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