Ion channel drug discovery / edited by Brian Cox, Martin Gosling, Horsham Research Centre, Horsham, UK.

Contributor(s):

Material type: Text

TextSeries: RSC drug discovery series ; 39.Publication details: Cambridge : Royal Society of Chemistry, c2015.Description: xviii, 366 p. : ill. ; 25 cmContent type:

text

Media type:

unmediated

Carrier type:

volume

ISBN:

9781849731867 (hb)
1849731861

Subject(s):

DDC classification:

615.19 22 I

LOC classification:

RM301.25 .I59 2015

NLM classification:

2015 A-381
QV 745

Online resources:

Abstract

Contents:

Ion channel drug discovery: a historical perspective / Brian Cox -- High-throughput screening / Alexander Böcker, Sabine Schaertl and Stephen D. Hess -- Automated electrophysiology in ion channel drug discovery / John Dunlop -- Structural understanding of ion channels in atomic detail / Phillip J. Stansfeld -- Voltage-gated sodium channels: structure, function, and molecular pharmacology / William A. Catterall -- AMPA receptor positive allosteric modulators: a case history / Simon E Ward -- The discovery of novel inhaled ENaC blockers for the treatment of cystic fibrosis lung disease / Catherine Howsham and Henry Danahay -- The therapeutic potential of small-molecule modulators of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl-channel / Jia Liu, Gerta Cami-Kobeci, Yiting Wang, Pissared Khuituan, Zhiwei Cai, Hongyu Li, Stephen M. Husbands and David N. Sheppard -- TRPV1 antagonism: from research to clinic / Mark S. Nash, J. Martin Verkuyl and Gurdip Bhalay -- Open access to the KCNQ channel: retigabine and second generation M-current openers / Johannes Krupp, Anthony M. Rush, Britt-Marie Swahn and Martin Main -- The therapeutic potential of hERG1 K+ channels for treating cancer and cardiac arrhythmias / John Mitcheson and Annarosa Arcangeli -- Does nature do ion channel drug discovery better than us? / Richard J. Lewis, Irina Vetter, Fernanda C. Cardoso, Marco Inserra and Glenn King -- Antibodies as ion channel modulators / Wilson Edwards and Alan D. Wickenden -- Ion channel drug discovery: future perspectives / Martin Gosling.

Summary: A rapidly growing field, this book covers the recent advances in screening technology, ion channel structure and modelling, with up-to-date case histories.

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Holdings
Item type	Current library	Collection	Call number	Status	Date due	Barcode
Books	Main library A10	Pharmacy ( Pharmacology )	615.19 I (Browse shelf(Opens below))	Available		00012971

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Includes bibliographical references and index.

Ion channel drug discovery: a historical perspective / Brian Cox --
High-throughput screening / Alexander Böcker, Sabine Schaertl and Stephen D. Hess --
Automated electrophysiology in ion channel drug discovery / John Dunlop --
Structural understanding of ion channels in atomic detail / Phillip J. Stansfeld --
Voltage-gated sodium channels: structure, function, and molecular pharmacology / William A. Catterall --
AMPA receptor positive allosteric modulators: a case history / Simon E Ward --
The discovery of novel inhaled ENaC blockers for the treatment of cystic fibrosis lung disease / Catherine Howsham and Henry Danahay --
The therapeutic potential of small-molecule modulators of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl-channel / Jia Liu, Gerta Cami-Kobeci, Yiting Wang, Pissared Khuituan, Zhiwei Cai, Hongyu Li, Stephen M. Husbands and David N. Sheppard --
TRPV1 antagonism: from research to clinic / Mark S. Nash, J. Martin Verkuyl and Gurdip Bhalay --
Open access to the KCNQ channel: retigabine and second generation M-current openers / Johannes Krupp, Anthony M. Rush, Britt-Marie Swahn and Martin Main --
The therapeutic potential of hERG1 K+ channels for treating cancer and cardiac arrhythmias / John Mitcheson and Annarosa Arcangeli --
Does nature do ion channel drug discovery better than us? / Richard J. Lewis, Irina Vetter, Fernanda C. Cardoso, Marco Inserra and Glenn King --
Antibodies as ion channel modulators / Wilson Edwards and Alan D. Wickenden --
Ion channel drug discovery: future perspectives / Martin Gosling.

A rapidly growing field, this book covers the recent advances in screening technology, ion channel structure and modelling, with up-to-date case histories.

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