A pharmaceutical study on colon-targeted delivery systems of an anti-inflammatory drug / Enas El-Maghawry Ibrahim, (assistant lecturer, department of Pharmaceutics & Pharmaceutical Technology, Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Future University in Egypt), supervision of Prof. Dr. Ahmed Abd-Elbary (Professor of Pharmaceutics and Industrial Pharmacy, Ex-Dean of Faculty of Pharmacy, Cairo University, Beni SweifUniversity), Prof. Dr. Seham Elkheshen, (Professor of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University), Prof. Dr. Mina Ibrahim Tadros, (Professor of Pharmaceutics and Industrial Pharmacy, Dean of Faculty of Pharmacy and Drug Technology, Egyptian Chinese University).

By:

Ibrahim, Enas El-Maghawry [author.]

Material type: Text

TextLanguage: English Summary language: Arabic Publisher: 2020Description: x, 212 pages, 6 pages : illustrations (some color) ; 24 cmContent type:

text

Media type:

unmediated

Carrier type:

volume

Other title:

دراسة صيدلية على بعض الأنظمة الهادفة للقولون المحتوية على عقار مضاد للالتهاب [Added title page title]

Subject(s):

DDC classification:

I.E.P 22 615.19

Online resources:

DSpace electronic resource

Dissertation note: Thesis (Ph.D.)- Cairo university, Faculty of pharmacy, Department of Pharmaceutics and industrial Pharmacy, 2020. Abstract: Colon-targeted drug delivery has been the focus of numerous studies due to its potential to improve treatment of local diseases affecting the colon, while minimizing systemic drug side effects. Some examples of the diseases which impact the colon include Crohn’s disease (CD) and ulcerative colitis (UC). In literature, different strategies have been used to target the inflamed colon after oral drug administration. Strategies for specific colon drug delivery include the utilization of pro-drugs, exploitation of higher colonic pH values, and enzymatic activity of colonic micro flora, intestinal transit time and colonic pressure. In general, dimensions of the delivery system greatly influence the targeting of the inflamed colon. Size-dependency of particles has a considerable impact on their epithelial uptake. A favoured accumulation in the inflamed colon tissues has been found for particles having sizes in the nanometer-range. It has been shown in experimental colitis models that nanosized particles are more readily uptaken by cells that are immune-related such as macrophages or dendritic cells in the site of active inflammation. The nano spray drying is one of the advanced technologies to produce nanoparticles. The nano spray dryer can produce relatively high yield of nanosized particles which possess narrow particle size distributions.

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Holdings
Item type	Current library	Collection	Call number	Status	Date due	Barcode
Thesis	Main library C5 PHD	Pharmacy ( Pharmaceutical Technology )	615.19 I.E.P (Browse shelf(Opens below))	Not for loan		00016479

supervision of Prof. Dr. Ahmed Abd-Elbary (Professor of Pharmaceutics and Industrial Pharmacy, Ex-Dean of Faculty of Pharmacy, Cairo University, Beni Sweif University), Prof. Dr. Seham Elkheshen, (Professor of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University), Prof. Dr. Mina Ibrahim Tadros, (Professor of Pharmaceutics and Industrial Pharmacy, Dean of Faculty of Pharmacy and Drug Technology, Egyptian Chinese University).

Thesis (Ph.D.)- Cairo university, Faculty of pharmacy, Department of Pharmaceutics and industrial Pharmacy, 2020.

Includes bibliographical references.

Colon-targeted drug delivery has been the focus of numerous studies due to its potential to improve treatment of local diseases affecting the colon, while minimizing systemic drug side effects. Some examples of the diseases which impact the colon include Crohn’s disease (CD) and ulcerative colitis (UC).
In literature, different strategies have been used to target the inflamed colon after oral drug administration. Strategies for specific colon drug delivery include the utilization of pro-drugs, exploitation of higher colonic pH values, and enzymatic activity of colonic micro flora, intestinal transit time and colonic pressure.
In general, dimensions of the delivery system greatly influence the targeting of the inflamed colon. Size-dependency of particles has a considerable impact on their epithelial uptake. A favoured accumulation in the inflamed colon tissues has been found for particles having sizes in the nanometer-range. It has been shown in experimental colitis models that nanosized particles are more readily uptaken by cells that are immune-related such as macrophages or dendritic cells in the site of active inflammation.
The nano spray drying is one of the advanced technologies to produce nanoparticles. The nano spray dryer can produce relatively high yield of nanosized particles which possess narrow particle size distributions.