Chemical and biological evaluation of bioactive secondary metabolites from endophytic fungi Isolated from marine organisms / By Yasmin Alaa Eldin Ahmed Elkhawas, assistant lecturer Pharmacognosy, Faculty of Pharmacy, Future University in Egypt.
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TextLanguage: English Summary language: Arabic Publisher: 2021Description: 140 pages, 3 pages : illustrations (black and white) ; 24 cmContent type: - text
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- التقييم الكميائي والحيوى لمركبات الأيض الثانوية النشطة حيويا من الفطريات المتكافلة المفصولة من الكائنات البحرية [Added title page title]
- 615.321 E.Y.C 22
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Thesis
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Main library C5 PHD | Pharmacy ( Pharmacognosy ) | 615.321 E.Y.C (Browse shelf(Opens below)) | Not for loan | 00016521 |
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Under the Supervision of Prof. Dr. Abdel Nasser B. Singab, Professor of Pharmacognosy, Head of Drug Discovery Research and Development Center- Faculty of Pharmacy- Ain Shams University, Prof. Dr. Osama M. Salama, Professor of Pharmacognosy, Former Vice President- Future University in Egypt, Associate Prof. Dr. Eman K. Alsayed, Associate Professor of Pharmacognosy, Faculty of Pharmacy - Ain Shams University, Associate Prof. Dr. Nada M. Mostafa, Associate Professor of Pharmacognosy, Faculty of Pharmacy - Ain Shams University, Dr. Mokhtar M. Bishr ,Technical Director, Plant Manager of Arab Co. For Pharmaceuticals & Medicinal Plants (Mepaco)
Thesis (Ph.D.)-Ain Shams university, Faculty of pharmacy, Department of Pharmacognosy, 2021.
Includes bibliographical references.
Two marine derived fungi were isolated from Red sea soft coral Sarcophyton ehrenbergi,
namely, Aspergillus flavus and A. nomius. These fungi were cultured using solid rice media.
Chromatographic studies on different extracts, resulted in isolation of 15 compounds. These
compounds were classified according to their chemical nature into six categories: (1) pyrones,
(2) cyclodepsipeptides, (3) diketopiperazines, (4) indoles, (5) benzo-furanones (6) steroids,
using different tools of spectroscopic techniques. Furthermore, these compounds were
confirmed by LC-MS/MS. Regarding the bioactivities of the extracts and the isolated
compounds, two compounds scopularides A & B from A. flavus showed antifungal, anti-H.
pylori and anti -TB activities
. Scopularide A showed potent antifungal, anti-H- pylori activities
while scopularide B revealed potent activity only against Candida albicans and H- pylori.
Moreover, the total extract of A. flavus showed larvicidal activity due to the presence of these
two scopularides. The larvicidal and antimicrobial activities were confirmed by carrying out
in-silico molecular docking against Candida albicans, A. niger, and also against certain
biochemical enzymes to identify the mode of action by which these tested samples exerts their
activity.
Text in English, abstracts in English and Arabic.
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