Design, Synthesis and Biological Evaluation of New Fused Piperidine Analogues as Anticancer Agents / by Mennatallah Mahmoud Abdelshaheed Bachelor of Pharmacy (Clinical Pharmacy), (2016) Faculty of Pharmacy, Mansoura University ; Supervisors : Prof. Dr. Hussein I. El-Subbagh Professor of Medicinal Chemistry, Faculty of Pharmacy, Mansoura Universit, Prof. Dr. Khairia M. Youssef Professor of Pharmaceutical Chemistry, Faculty of Pharmacy, Future University in Egypt, Dr. Iten M. Fawzy Lecturer of Pharmaceutical Chemistry, Faculty of Pharmacy, Future University in Egypt.

Supervisors : Prof. Dr. Hussein I. El-Subbagh, Professor of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Prof. Dr. Khairia M. Youssef, Professor of Pharmaceutical Chemistry, Faculty of Pharmacy, Future University in Egypt, Dr. Iten M. Fawzy, Lecturer of Pharmaceutical Chemistry, Faculty of Pharmacy, Future University in Egypt.

Thesis (M.Sc.)--Future University in Egypt, Faculty of pharmacy, Medicinal Chemistry, 2022.

Includes bibliographical references (pages 104- 124).

Cancer is a serious health problem and is one of the leading causes of death worldwide.
Piperidine is an essential pharmacophore and a favoured scaffold in the field of drug design.
Piperidine nucleus exhibited great potential in chemotherapy. Previous studies have reported
the antiproliferative effect of piperidine moiety against different cancer cell lines. Piperidine
was found to be able to cause tubulin inhibition and induce apoptosis and cell cycle arrest in
various types of cancer cells. In this thesis four different series of piperidine derivatives
inspired by Curcumin were designed, synthesised, and tested in vivo and in vitro for their
antitumor effect.

Text in English, abstract in English and Arabic.