Advanced practical organic chemistry / John Leonard, Barry Lygo, Garry Procter.

By:

Leonard, J. (John), 1954- [author.]

Contributor(s):

Material type: Text

TextPublisher: Boca Raton : CRC Press, Taylor & Francis Group, [2018]Edition: Third edition / John Leonard, Barry Lygo, Garry ProcterDescription: xxv, 330 pages : illustrations ; 24 cmContent type:

text

Media type:

unmediated

Carrier type:

volume

ISBN:

9781439860977 (paperback)

Subject(s):

DDC classification:

547.0078 23 L.J.A

LOC classification:

QD251.3 .L46 2013

Contents:

General introduction Safety Safety is your primary responsibility Safe working practice Safety risk assessments Common hazards Accident and emergency procedures Bibliography Keeping records of laboratory work Introduction The laboratory notebook Keeping records of data Some tips on report and thesis preparation References Equipping the laboratory and the bench Introduction Setting up the laboratory General laboratory equipment The individual bench Equipment for parallel experiments Equipment for controlled experimentation Purification and drying of solvents Introduction Purification of solvents Drying agents Drying of solvents References Reagents: Preparation, purification, and handling Introduction Classification of reagents for handling Techniques for obtaining pure and dry reagents Techniques for handling and measuring reagents Preparation and titration of simple organometallic reagents and lithium amide bases Preparation of diazomethane References Gases Introduction Use of gas cylinders Handling gases Measurement of gases Inert gases Reagent gases References Vacuum pumps Introduction House vacuum systems (low vacuum) Medium vacuum pumps High vacuum pumps Pressure measurement and regulation Carrying out the reaction Introduction Reactions with air-sensitive reagents Reaction monitoring Reactions at other than room temperature Driving equilibria Agitation Use of controlled reactor systems References Working up the reaction Introduction Quenching the reaction Isolation of the crude product Data that need to be collected on the crude product prior to purification Purification Introduction Crystallization Distillation Sublimation Flash chromatography Dry-column flash chromatography Preparative TLC Medium pressure and prepacked chromatography systems Preparative HPLC References Small-scale reactions Introduction Reactions at or below room temperature Reactions above room temperature Reactions in NMR tubes Purification of materials Large-scale reactions Introduction Carrying out the reaction Workup and product isolation Purification of the products Special procedures Introduction Catalytic hydrogenation Photolysis Ozonolysis Flash vacuum pyrolysis (FVP) Liquid ammonia reactions Microwave reactions References Characterization Introduction NMR spectra IR spectra UV spectroscopy Mass spectrometry Melting point (m.p.) and boiling point (b.p.) Optical rotation Microanalysis Keeping the data Troubleshooting: What to do when things don’t work The chemical literature The structure of the chemical literature Some important paper-based sources of chemical information Some important electronic-based sources of chemical information How to find chemical information Current awareness References Appendices Properties of common solvents Properties of common gases Approximate pKa values for some common reagents versus common bases Common Bronsted acids Common Lewis acids Common reducing reagents Common oxidizing reagents Index

Summary: With an emphasis on the most up-to-date techniques commonly used in organic synthesis, this third edition reference draws on the extensive experience of the authors and their association with some of the world' s leading laboratories of synthetic organic chemistry. Written mainly for postgraduate, advanced undergraduate, and industrial organic chemists, this book emphasizes understanding rather than learning facts and offers fully updated information and re-drawn figures to illustrate the information at the highest possible standard. The increased size ...

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Holdings
Item type	Current library	Collection	Call number	Status	Date due	Barcode
Books	Main library A9	Pharmacy ( Pharmaceutical chemistry )	547.0078 L.J.A (Browse shelf(Opens below))	Available		00015153

Includes bibliographical references and index.

General introduction

Safety
Safety is your primary responsibility
Safe working practice
Safety risk assessments
Common hazards
Accident and emergency procedures
Bibliography

Keeping records of laboratory work
Introduction
The laboratory notebook
Keeping records of data
Some tips on report and thesis preparation
References

Equipping the laboratory and the bench
Introduction
Setting up the laboratory
General laboratory equipment
The individual bench
Equipment for parallel experiments
Equipment for controlled experimentation

Purification and drying of solvents
Introduction
Purification of solvents
Drying agents
Drying of solvents
References

Reagents: Preparation, purification, and handling
Introduction
Classification of reagents for handling
Techniques for obtaining pure and dry reagents
Techniques for handling and measuring reagents
Preparation and titration of simple organometallic reagents and lithium amide bases
Preparation of diazomethane
References

Gases
Introduction
Use of gas cylinders
Handling gases
Measurement of gases
Inert gases
Reagent gases
References

Vacuum pumps
Introduction
House vacuum systems (low vacuum)
Medium vacuum pumps
High vacuum pumps
Pressure measurement and regulation

Carrying out the reaction
Introduction
Reactions with air-sensitive reagents
Reaction monitoring
Reactions at other than room temperature
Driving equilibria
Agitation
Use of controlled reactor systems
References

Working up the reaction
Introduction
Quenching the reaction
Isolation of the crude product
Data that need to be collected on the crude product prior to purification

Purification
Introduction
Crystallization
Distillation
Sublimation
Flash chromatography
Dry-column flash chromatography
Preparative TLC
Medium pressure and prepacked chromatography systems
Preparative HPLC
References

Small-scale reactions
Introduction
Reactions at or below room temperature
Reactions above room temperature
Reactions in NMR tubes
Purification of materials

Large-scale reactions
Introduction
Carrying out the reaction
Workup and product isolation
Purification of the products

Special procedures
Introduction
Catalytic hydrogenation
Photolysis
Ozonolysis
Flash vacuum pyrolysis (FVP)
Liquid ammonia reactions
Microwave reactions
References

Characterization
Introduction
NMR spectra
IR spectra
UV spectroscopy
Mass spectrometry
Melting point (m.p.) and boiling point (b.p.)
Optical rotation
Microanalysis
Keeping the data

Troubleshooting: What to do when things don’t work

The chemical literature
The structure of the chemical literature
Some important paper-based sources of chemical information
Some important electronic-based sources of chemical information
How to find chemical information
Current awareness
References

Appendices
Properties of common solvents
Properties of common gases
Approximate pKa values for some common reagents versus common bases
Common Bronsted acids
Common Lewis acids
Common reducing reagents
Common oxidizing reagents

Index

With an emphasis on the most up-to-date techniques commonly used in organic synthesis, this third edition reference draws on the extensive experience of the authors and their association with some of the world' s leading laboratories of synthetic organic chemistry. Written mainly for postgraduate, advanced undergraduate, and industrial organic chemists, this book emphasizes understanding rather than learning facts and offers fully updated information and re-drawn figures to illustrate the information at the highest possible standard. The increased size ...

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