Study of the effect of lubricants on the physicochemical properties of certain polymeric films / Aya Mohamed Adel Abdel Halim Fouly ; Supervisors Hussein Ammar, Mamdouh Ghorab, Shadid Gad Abdulrahman.

Supervisor : Hussein Amaar.

Thesis (M.Sc)-Suez Canal university, Faculty of pharmacy, Department of Pharmaceutics, 2014.

Includes bibliographical references.

Solid dosage forms represent a great share of the pharmaceutical production due<br>to being; stable, easier for shipping and handling and have longer expiration<br>dates. In addition, solid dosage forms require less shelf space, do not require<br>preservation and have accurate dosage (single dose).<br>Coating represents a very important operation during the production of solid<br>dosage forms either due to enhancing tablet flowability and line clearance or due<br>to functional and patient adherence related issues.<br>Polymeric film coating is CHARacterized over other coating methodologies by its<br>quality, operational efficiency, safety and profit. Aqueous-based systems have<br>gained popularity over solvent-based systems due to their lower toxicity levels<br>and environment friendly standpoint.<br>Eudragit® acrylic resins have been widely used in the pharmaceutical industry,<br>they are CHARacterized by being water insoluble but swellable polymers.<br>Antiadherents are very common additives during aqueous acrylic polymeric<br>film coating so as to avoid susceptible stickiness or tackiness of polymeric films<br>which is a concern during both coating process and storage.<br>Talc is considered to be one of the most frequently used antiadherents specially<br>in the Egyptian market due to its low price and is CHARacterized by its<br>hydrophobic nature, Glyceryl monostearate (GMS) has been used as an<br>alternative for talc and is known by its waxy nature. The ready-to-use<br>PlasacrylTM T20 suspension which contains GMS as an antiadherent, triethyl<br>Abstract<br>ii<br>citrate as a plasticizer and polysorbate 80 as a surfactant has been recently used<br>with Eudragit® polymers.<br>In spite of being a corner stone in the treatment of the unwanted tablet<br>agglomeration during coating, antiadherents may be causative factor for many<br>changes in either the physicochemical properties or the dissolution properties of<br>acrylic polymeric film coating systems.<br>Polymer films must be mechanically strong such that they do not break or<br>fracture during processing, packaging, shipping, and storage.<br>Generally, particles coated with a film behave differently from the film itself.<br>However, there is no doubt that studies conducted on free films help to<br>understand the behavior of dosage forms coated with these films. Free films can<br>be obtained by the casting method, where a polymeric solution or dispersion is<br>cast onto a n

Text in English, abstracts in English and Arabic.